Wang R - Search Results

1

Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death.

Jiang D, Chen W, Wang R, Zhang L, Chen SR. Jiang D, et al. Among authors: wang r. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18309-14. doi: 10.1073/pnas.0706573104. Epub 2007 Nov 1. Proc Natl Acad Sci U S A. 2007. PMID: 17984046 Free PMC article.

2

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

Xiao B, Masumiya H, Jiang D, Wang R, Sei Y, Zhang L, Murayama T, Ogawa Y, Lai FA, Wagenknecht T, Chen SR. Xiao B, et al. Among authors: wang r. J Biol Chem. 2002 Nov 1;277(44):41778-85. doi: 10.1074/jbc.M208210200. Epub 2002 Sep 3. J Biol Chem. 2002. PMID: 12213830 Free article.

3

Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor).

Masumiya H, Wang R, Zhang J, Xiao B, Chen SR. Masumiya H, et al. Among authors: wang r. J Biol Chem. 2003 Feb 7;278(6):3786-92. doi: 10.1074/jbc.M210962200. Epub 2002 Nov 22. J Biol Chem. 2003. PMID: 12446682 Free article.

4

Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites.

Zhang J, Liu Z, Masumiya H, Wang R, Jiang D, Li F, Wagenknecht T, Chen SR. Zhang J, et al. Among authors: wang r. J Biol Chem. 2003 Apr 18;278(16):14211-8. doi: 10.1074/jbc.M213164200. Epub 2003 Feb 7. J Biol Chem. 2003. PMID: 12576471 Free article.

5

Residue Gln4863 within a predicted transmembrane sequence of the Ca2+ release channel (ryanodine receptor) is critical for ryanodine interaction.

Wang R, Zhang L, Bolstad J, Diao N, Brown C, Ruest L, Welch W, Williams AJ, Chen SR. Wang R, et al. J Biol Chem. 2003 Dec 19;278(51):51557-65. doi: 10.1074/jbc.M306788200. Epub 2003 Oct 13. J Biol Chem. 2003. PMID: 14557272 Free article.

6

The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gating.

Wang R, Bolstad J, Kong H, Zhang L, Brown C, Chen SR. Wang R, et al. J Biol Chem. 2004 Jan 30;279(5):3635-42. doi: 10.1074/jbc.M311367200. Epub 2003 Oct 30. J Biol Chem. 2004. PMID: 14593104 Free article.

7

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR).

Jiang D, Xiao B, Yang D, Wang R, Choi P, Zhang L, Cheng H, Chen SR. Jiang D, et al. Among authors: wang r. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13062-7. doi: 10.1073/pnas.0402388101. Epub 2004 Aug 20. Proc Natl Acad Sci U S A. 2004. PMID: 15322274 Free PMC article.

8

The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance.

Ranatunga KM, Moreno-King TM, Tanna B, Wang R, Chen SR, Ruest L, Welch W, Williams AJ. Ranatunga KM, et al. Among authors: wang r. Mol Pharmacol. 2005 Sep;68(3):840-6. doi: 10.1124/mol.105.012807. Epub 2005 Jun 14. Mol Pharmacol. 2005. PMID: 15955866

9

Localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptor.

Liu Z, Wang R, Zhang J, Chen SR, Wagenknecht T. Liu Z, et al. Among authors: wang r. J Biol Chem. 2005 Nov 11;280(45):37941-7. doi: 10.1074/jbc.M505714200. Epub 2005 Sep 11. J Biol Chem. 2005. PMID: 16157601 Free PMC article.

10

Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death.

Jiang D, Wang R, Xiao B, Kong H, Hunt DJ, Choi P, Zhang L, Chen SR. Jiang D, et al. Among authors: wang r. Circ Res. 2005 Nov 25;97(11):1173-81. doi: 10.1161/01.RES.0000192146.85173.4b. Epub 2005 Oct 20. Circ Res. 2005. PMID: 16239587

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