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Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives.
O'Brien PM, Sliskovic DR, Picard JA, Lee HT, Purchase CF 2nd, Roth BD, White AD, Anderson M, Mueller SB, Bocan T, Bousley R, Hamelehle KL, Homan R, Lee P, Krause BR, Reindel JF, Stanfield RL, Turluck D. O'Brien PM, et al. Among authors: hamelehle kl. J Med Chem. 1996 Jun 7;39(12):2354-66. doi: 10.1021/jm960170f. J Med Chem. 1996. PMID: 8691430
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
Sliskovic DR, Krause BR, Picard JA, Anderson M, Bousley RF, Hamelehle KL, Homan R, Julian TN, Rashidbaigi ZA, Stanfield RL. Sliskovic DR, et al. Among authors: hamelehle kl. J Med Chem. 1994 Mar 4;37(5):560-2. doi: 10.1021/jm00031a002. J Med Chem. 1994. PMID: 8126693 No abstract available.
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets.
Lee HT, Sliskovic DR, Picard JA, Roth BD, Wierenga W, Hicks JL, Bousley RF, Hamelehle KL, Homan R, Speyer C, Stanfield RL, Krause BR. Lee HT, et al. Among authors: hamelehle kl. J Med Chem. 1996 Dec 20;39(26):5031-4. doi: 10.1021/jm960674d. J Med Chem. 1996. PMID: 8978833 No abstract available.
23 results