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Page 1
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.
Toral-Barza L, Zhang WG, Huang X, McDonald LA, Salaski EJ, Barbieri LR, Ding WD, Krishnamurthy G, Hu YB, Lucas J, Bernan VS, Cai P, Levin JI, Mansour TS, Gibbons JJ, Abraham RT, Yu K. Toral-Barza L, et al. Among authors: ding wd. Mol Cancer Ther. 2007 Nov;6(11):3028-38. doi: 10.1158/1535-7163.MCT-07-0211. Epub 2007 Nov 7. Mol Cancer Ther. 2007. PMID: 17989320
Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.
Salaski EJ, Krishnamurthy G, Ding WD, Yu K, Insaf SS, Eid C, Shim J, Levin JI, Tabei K, Toral-Barza L, Zhang WG, McDonald LA, Honores E, Hanna C, Yamashita A, Johnson B, Li Z, Laakso L, Powell D, Mansour TS. Salaski EJ, et al. Among authors: ding wd. J Med Chem. 2009 Apr 23;52(8):2181-4. doi: 10.1021/jm900075g. J Med Chem. 2009. PMID: 19309081
Novel and specific respiratory syncytial virus inhibitors that target virus fusion.
Ding WD, Mitsner B, Krishnamurthy G, Aulabaugh A, Hess CD, Zaccardi J, Cutler M, Feld B, Gazumyan A, Raifeld Y, Nikitenko A, Lang SA, Gluzman Y, O'Hara B, Ellestad GA. Ding WD, et al. J Med Chem. 1998 Jul 16;41(15):2671-5. doi: 10.1021/jm980239e. J Med Chem. 1998. PMID: 9667956 No abstract available.
Flavins inhibit human cytomegalovirus UL80 protease via disulfide bond formation.
Baum EZ, Ding WD, Siegel MM, Hulmes J, Bebernitz GA, Sridharan L, Tabei K, Krishnamurthy G, Carofiglio T, Groves JT, Bloom JD, DiGrandi M, Bradley M, Ellestad G, Seddon AP, Gluzman Y. Baum EZ, et al. Among authors: ding wd. Biochemistry. 1996 May 7;35(18):5847-55. doi: 10.1021/bi9529972. Biochemistry. 1996. PMID: 8639546
27 results