Huang X - Search Results

1

Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.

Toral-Barza L, Zhang WG, Huang X, McDonald LA, Salaski EJ, Barbieri LR, Ding WD, Krishnamurthy G, Hu YB, Lucas J, Bernan VS, Cai P, Levin JI, Mansour TS, Gibbons JJ, Abraham RT, Yu K. Toral-Barza L, et al. Among authors: huang x. Mol Cancer Ther. 2007 Nov;6(11):3028-38. doi: 10.1158/1535-7163.MCT-07-0211. Epub 2007 Nov 7. Mol Cancer Ther. 2007. PMID: 17989320

2

Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening.

Hao W, Hu Y, Niu C, Huang X, Chang CP, Gibbons J, Xu J. Hao W, et al. Among authors: huang x. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4988-92. doi: 10.1016/j.bmcl.2008.08.032. Epub 2008 Aug 14. Bioorg Med Chem Lett. 2008. PMID: 18768317

3

Kinetic mechanism of Staphylococcus aureus sortase SrtA.

Huang X, Aulabaugh A, Ding W, Kapoor B, Alksne L, Tabei K, Ellestad G. Huang X, et al. Biochemistry. 2003 Sep 30;42(38):11307-15. doi: 10.1021/bi034391g. Biochemistry. 2003. PMID: 14503881

4

Development of an HPLC assay for Staphylococcus aureus sortase: evidence for the formation of the kinetically competent acyl enzyme intermediate.

Aulabaugh A, Ding W, Kapoor B, Tabei K, Alksne L, Dushin R, Zatz T, Ellestad G, Huang X. Aulabaugh A, et al. Among authors: huang x. Anal Biochem. 2007 Jan 1;360(1):14-22. doi: 10.1016/j.ab.2006.10.021. Epub 2006 Nov 3. Anal Biochem. 2007. PMID: 17107653

5

Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.

Cole DC, Asselin M, Brennan A, Czerwinski R, Ellingboe JW, Fitz L, Greco R, Huang X, Joseph-McCarthy D, Kelly MF, Kirisits M, Lee J, Li Y, Morgan P, Stock JR, Tsao DH, Wissner A, Yang X, Chaudhary D. Cole DC, et al. Among authors: huang x. J Med Chem. 2008 Oct 9;51(19):5958-63. doi: 10.1021/jm800214a. Epub 2008 Sep 11. J Med Chem. 2008. PMID: 18783200

6

Biochemical and biophysical characterization of inhibitor binding to caspase-3 reveals induced asymmetry.

Aulabaugh A, Kapoor B, Huang X, Dollings P, Hum WT, Banker A, Wood A, Ellestad G. Aulabaugh A, et al. Among authors: huang x. Biochemistry. 2007 Aug 21;46(33):9462-71. doi: 10.1021/bi7000505. Epub 2007 Jul 25. Biochemistry. 2007. PMID: 17649976

7

Fluorescence polarization competition assay: the range of resolvable inhibitor potency is limited by the affinity of the fluorescent ligand.

Huang X. Huang X. J Biomol Screen. 2003 Feb;8(1):34-8. doi: 10.1177/1087057102239666. J Biomol Screen. 2003. PMID: 12854996

8

A continuous fluorimetric assay for tumor necrosis factor-alpha converting enzyme.

Jin G, Huang X, Black R, Wolfson M, Rauch C, McGregor H, Ellestad G, Cowling R. Jin G, et al. Among authors: huang x. Anal Biochem. 2002 Mar 15;302(2):269-75. doi: 10.1006/abio.2001.5549. Anal Biochem. 2002. PMID: 11878807

9

Equilibrium competition binding assay: inhibition mechanism from a single dose response.

Huang X. Huang X. J Theor Biol. 2003 Dec 7;225(3):369-76. doi: 10.1016/s0022-5193(03)00265-0. J Theor Biol. 2003. PMID: 14604589

10

Application of fluorescence polarization in HTS assays.

Huang X, Aulabaugh A. Huang X, et al. Methods Mol Biol. 2009;565:127-43. doi: 10.1007/978-1-60327-258-2_6. Methods Mol Biol. 2009. PMID: 19551360

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