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Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.
Duan L, Miura Y, Dimri M, Majumder B, Dodge IL, Reddi AL, Ghosh A, Fernandes N, Zhou P, Mullane-Robinson K, Rao N, Donoghue S, Rogers RA, Bowtell D, Naramura M, Gu H, Band V, Band H. Duan L, et al. J Biol Chem. 2003 Aug 1;278(31):28950-60. doi: 10.1074/jbc.M304474200. Epub 2003 May 18. J Biol Chem. 2003. PMID: 12754251 Free article.
Osteopenia in Siah1a mutant mice.
Frew IJ, Sims NA, Quinn JM, Walkley CR, Purton LE, Bowtell DD, Gillespie MT. Frew IJ, et al. Among authors: bowtell dd. J Biol Chem. 2004 Jul 9;279(28):29583-8. doi: 10.1074/jbc.M312755200. Epub 2004 May 3. J Biol Chem. 2004. PMID: 15123657 Free article.
Elucidation of the substrate binding site of Siah ubiquitin ligase.
House CM, Hancock NC, Möller A, Cromer BA, Fedorov V, Bowtell DD, Parker MW, Polekhina G. House CM, et al. Among authors: bowtell dd. Structure. 2006 Apr;14(4):695-701. doi: 10.1016/j.str.2005.12.013. Structure. 2006. PMID: 16615911 Free article.
Inhibition of Siah ubiquitin ligase function.
Möller A, House CM, Wong CS, Scanlon DB, Liu MC, Ronai Z, Bowtell DD. Möller A, et al. Among authors: bowtell dd. Oncogene. 2009 Jan 15;28(2):289-96. doi: 10.1038/onc.2008.382. Epub 2008 Oct 13. Oncogene. 2009. PMID: 18850011 Free PMC article.
The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression.
Chan P, Möller A, Liu MC, Sceneay JE, Wong CS, Waddell N, Huang KT, Dobrovic A, Millar EK, O'Toole SA, McNeil CM, Sutherland RL, Bowtell DD, Fox SB. Chan P, et al. Among authors: bowtell dd. Breast Cancer Res. 2011 Feb 9;13(1):R19. doi: 10.1186/bcr2828. Breast Cancer Res. 2011. PMID: 21306611 Free PMC article.
360 results