Wang S - Search Results

1

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

Sun H, Nikolovska-Coleska Z, Lu J, Meagher JL, Yang CY, Qiu S, Tomita Y, Ueda Y, Jiang S, Krajewski K, Roller PP, Stuckey JA, Wang S. Sun H, et al. Among authors: wang s. J Am Chem Soc. 2007 Dec 12;129(49):15279-94. doi: 10.1021/ja074725f. Epub 2007 Nov 14. J Am Chem Soc. 2007. PMID: 17999504 Free PMC article.

2

Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.

Zhang M, Liu H, Guo R, Ling Y, Wu X, Li B, Roller PP, Wang S, Yang D. Zhang M, et al. Among authors: wang s. Biochem Pharmacol. 2003 Jul 1;66(1):93-103. doi: 10.1016/s0006-2952(03)00248-x. Biochem Pharmacol. 2003. PMID: 12818369

3

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.

Nikolovska-Coleska Z, Xu L, Hu Z, Tomita Y, Li P, Roller PP, Wang R, Fang X, Guo R, Zhang M, Lippman ME, Yang D, Wang S. Nikolovska-Coleska Z, et al. Among authors: wang s, wang r. J Med Chem. 2004 May 6;47(10):2430-40. doi: 10.1021/jm030420+. J Med Chem. 2004. PMID: 15115387

4

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Tomita Y, Krajewski K, Roller PP, Wang S. Sun H, et al. Among authors: wang s. J Med Chem. 2004 Aug 12;47(17):4147-50. doi: 10.1021/jm0499108. J Med Chem. 2004. PMID: 15293984

5

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

Nikolovska-Coleska Z, Wang R, Fang X, Pan H, Tomita Y, Li P, Roller PP, Krajewski K, Saito NG, Stuckey JA, Wang S. Nikolovska-Coleska Z, et al. Among authors: wang s, wang r. Anal Biochem. 2004 Sep 15;332(2):261-73. doi: 10.1016/j.ab.2004.05.055. Anal Biochem. 2004. PMID: 15325294

6

Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein.

Koehler NK, Yang CY, Varady J, Lu Y, Wu XW, Liu M, Yin D, Bartels M, Xu BY, Roller PP, Long YQ, Li P, Kattah M, Cohn ML, Moran K, Tilley E, Richert JR, Wang S. Koehler NK, et al. Among authors: wang s. J Med Chem. 2004 Oct 7;47(21):4989-97. doi: 10.1021/jm030362s. J Med Chem. 2004. PMID: 15456243

7

Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2.

Real PJ, Cao Y, Wang R, Nikolovska-Coleska Z, Sanz-Ortiz J, Wang S, Fernandez-Luna JL. Real PJ, et al. Among authors: wang s, wang r. Cancer Res. 2004 Nov 1;64(21):7947-53. doi: 10.1158/0008-5472.CAN-04-0945. Cancer Res. 2004. PMID: 15520201

8

Structure-based design of potent, conformationally constrained Smac mimetics.

Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Liu M, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Sun H, et al. Among authors: wang s. J Am Chem Soc. 2004 Dec 29;126(51):16686-7. doi: 10.1021/ja047438+. J Am Chem Soc. 2004. PMID: 15612682

9

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.

Sun H, Nikolovska-Coleska Z, Chen J, Yang CY, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Sun H, et al. Among authors: wang s. Bioorg Med Chem Lett. 2005 Feb 1;15(3):793-7. doi: 10.1016/j.bmcl.2004.11.008. Bioorg Med Chem Lett. 2005. PMID: 15664859

10

Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands.

Ji M, Chen J, Ding K, Wu X, Varady J, Levant B, Wang S. Ji M, et al. Among authors: wang s. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1701-5. doi: 10.1016/j.bmcl.2005.01.037. Bioorg Med Chem Lett. 2005. PMID: 15745825

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