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Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-kappaB activation in airway epithelium and promotes lung inflammation and tumorigenesis.
Deng J, Fujimoto J, Ye XF, Men TY, Van Pelt CS, Chen YL, Lin XF, Kadara H, Tao Q, Lotan D, Lotan R. Deng J, et al. Among authors: van pelt cs. Cancer Prev Res (Phila). 2010 Apr;3(4):424-37. doi: 10.1158/1940-6207.CAPR-10-0032. Epub 2010 Mar 30. Cancer Prev Res (Phila). 2010. PMID: 20354164 Free PMC article.
Multiple stress signals activate mutant p53 in vivo.
Suh YA, Post SM, Elizondo-Fraire AC, Maccio DR, Jackson JG, El-Naggar AK, Van Pelt C, Terzian T, Lozano G. Suh YA, et al. Cancer Res. 2011 Dec 1;71(23):7168-75. doi: 10.1158/0008-5472.CAN-11-0459. Epub 2011 Oct 7. Cancer Res. 2011. PMID: 21983037 Free PMC article.
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