Kumar S - Search Results

1

Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediates.

Pearson JT, Wahlstrom JL, Dickmann LJ, Kumar S, Halpert JR, Wienkers LC, Foti RS, Rock DA. Pearson JT, et al. Among authors: kumar s. Chem Res Toxicol. 2007 Dec;20(12):1778-86. doi: 10.1021/tx700207u. Epub 2007 Nov 15. Chem Res Toxicol. 2007. PMID: 18001057

2

Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate.

Davydov DR, Kumar S, Halpert JR. Davydov DR, et al. Among authors: kumar s. Biochem Biophys Res Commun. 2002 Jun 21;294(4):806-12. doi: 10.1016/S0006-291X(02)00565-X. Biochem Biophys Res Commun. 2002. PMID: 12061778

3

A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.

Kumar S, Scott EE, Liu H, Halpert JR. Kumar S, et al. J Biol Chem. 2003 May 9;278(19):17178-84. doi: 10.1074/jbc.M212515200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12609983 Free article.

4

An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.

Davydov DR, Botchkareva AE, Kumar S, He YQ, Halpert JR. Davydov DR, et al. Among authors: kumar s. Biochemistry. 2004 Jun 1;43(21):6475-85. doi: 10.1021/bi036260l. Biochemistry. 2004. PMID: 15157081

5

Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide.

Kumar S, Chen CS, Waxman DJ, Halpert JR. Kumar S, et al. J Biol Chem. 2005 May 20;280(20):19569-75. doi: 10.1074/jbc.M500158200. Epub 2005 Mar 17. J Biol Chem. 2005. PMID: 15774478 Free article.

6

Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

Kumar S, Davydov DR, Halpert JR. Kumar S, et al. Drug Metab Dispos. 2005 Aug;33(8):1131-6. doi: 10.1124/dmd.105.004606. Epub 2005 May 3. Drug Metab Dispos. 2005. PMID: 15870379

7

Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts.

Kumar S, Halpert JR. Kumar S, et al. Biochem Biophys Res Commun. 2005 Dec 9;338(1):456-64. doi: 10.1016/j.bbrc.2005.08.080. Epub 2005 Aug 22. Biochem Biophys Res Commun. 2005. PMID: 16126165 Review.

8

Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.

Kumar S, Liu H, Halpert JR. Kumar S, et al. Drug Metab Dispos. 2006 Dec;34(12):1958-65. doi: 10.1124/dmd.106.012054. Epub 2006 Sep 20. Drug Metab Dispos. 2006. PMID: 16987939

9

Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme.

Hernandez CE, Kumar S, Liu H, Halpert JR. Hernandez CE, et al. Among authors: kumar s. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7. doi: 10.1016/j.abb.2006.08.024. Epub 2006 Sep 25. Arch Biochem Biophys. 2006. PMID: 17027909 Free PMC article.

10

Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.

Kumar S, Sun L, Liu H, Muralidhara BK, Halpert JR. Kumar S, et al. Protein Eng Des Sel. 2006 Dec;19(12):547-54. doi: 10.1093/protein/gzl042. Epub 2006 Oct 18. Protein Eng Des Sel. 2006. PMID: 17050590

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