Rock DA - Search Results

1

Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediates.

Pearson JT, Wahlstrom JL, Dickmann LJ, Kumar S, Halpert JR, Wienkers LC, Foti RS, Rock DA. Pearson JT, et al. Among authors: rock da. Chem Res Toxicol. 2007 Dec;20(12):1778-86. doi: 10.1021/tx700207u. Epub 2007 Nov 15. Chem Res Toxicol. 2007. PMID: 18001057

2

Assessment of the metabolism and intrinsic reactivity of a novel catechol metabolite.

Hutzler JM, Melton RJ, Rumsey JM, Thompson DC, Rock DA, Wienkers LC. Hutzler JM, et al. Among authors: rock da. Chem Res Toxicol. 2008 May;21(5):1125-33. doi: 10.1021/tx700429v. Epub 2008 Apr 12. Chem Res Toxicol. 2008. PMID: 18407675

3

The combination of chemical and antibody inhibitors for superior P450 3A inhibition in reaction phenotyping studies.

Rock DA, Foti RS, Pearson JT. Rock DA, et al. Drug Metab Dispos. 2008 Dec;36(12):2410-3. doi: 10.1124/dmd.108.023572. Epub 2008 Sep 2. Drug Metab Dispos. 2008. PMID: 18765682

4

Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction.

Foti RS, Rock DA, Pearson JT, Wahlstrom JL, Wienkers LC. Foti RS, et al. Among authors: rock da. Drug Metab Dispos. 2011 Jul;39(7):1188-95. doi: 10.1124/dmd.111.038505. Epub 2011 Mar 29. Drug Metab Dispos. 2011. PMID: 21447734

5

Formation of raloxifene homo-dimer in CYP3A4, evidence for multi-substrate binding in a single catalytically competent P450 active site.

Davis JA, Greene RJ, Han S, Rock DA, Wienkers LC. Davis JA, et al. Among authors: rock da. Arch Biochem Biophys. 2011 Sep 15;513(2):110-8. doi: 10.1016/j.abb.2011.06.016. Epub 2011 Jul 13. Arch Biochem Biophys. 2011. PMID: 21767526

6

Cytochrome p450 architecture and cysteine nucleophile placement impact raloxifene-mediated mechanism-based inactivation.

VandenBrink BM, Davis JA, Pearson JT, Foti RS, Wienkers LC, Rock DA. VandenBrink BM, et al. Among authors: rock da. Mol Pharmacol. 2012 Nov;82(5):835-42. doi: 10.1124/mol.112.080739. Epub 2012 Aug 2. Mol Pharmacol. 2012. PMID: 22859722

7

Characterization of ritonavir-mediated inactivation of cytochrome P450 3A4.

Rock BM, Hengel SM, Rock DA, Wienkers LC, Kunze KL. Rock BM, et al. Among authors: rock da. Mol Pharmacol. 2014 Dec;86(6):665-74. doi: 10.1124/mol.114.094862. Epub 2014 Oct 1. Mol Pharmacol. 2014. PMID: 25274602

8

Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation.

Baer BR, Wienkers LC, Rock DA. Baer BR, et al. Among authors: rock da. Chem Res Toxicol. 2007 Jun;20(6):954-64. doi: 10.1021/tx700037e. Epub 2007 May 12. Chem Res Toxicol. 2007. PMID: 17497897

9

Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements.

Foti RS, Dickmann LJ, Davis JA, Greene RJ, Hill JJ, Howard ML, Pearson JT, Rock DA, Tay JC, Wahlstrom JL, Slatter JG. Foti RS, et al. Among authors: rock da. Xenobiotica. 2008 Mar;38(3):264-80. doi: 10.1080/00498250701802514. Xenobiotica. 2008. PMID: 18274956

10

In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract.

Foti RS, Pearson JT, Rock DA, Wahlstrom JL, Wienkers LC. Foti RS, et al. Among authors: rock da. Drug Metab Dispos. 2009 Sep;37(9):1848-55. doi: 10.1124/dmd.109.028043. Epub 2009 Jun 18. Drug Metab Dispos. 2009. PMID: 19541824

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