de Mol NJ - Search Results

1

A photoswitchable ITAM peptidomimetic: synthesis and real time surface plasmon resonance (SPR) analysis of the effects of cis-trans isomerization on binding.

Kuil J, van Wandelen LT, de Mol NJ, Liskamp RM. Kuil J, et al. Among authors: de mol nj. Bioorg Med Chem. 2008 Feb 1;16(3):1393-9. doi: 10.1016/j.bmc.2007.10.049. Epub 2007 Oct 22. Bioorg Med Chem. 2008. PMID: 18024135

2

Role of solution conformation and flexibility of short peptide ligands that bind to the p56(lck) SH2 domain.

Dekker FJ, de Mol NJ, Bultinck P, Kemmink J, Hilbers HW, Liskamp RM. Dekker FJ, et al. Among authors: de mol nj. Bioorg Med Chem. 2003 Mar 20;11(6):941-9. doi: 10.1016/s0968-0896(02)00536-9. Bioorg Med Chem. 2003. PMID: 12614879

3

Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand.

Dekker FJ, de Mol NJ, Fischer MJ, Liskamp RM. Dekker FJ, et al. Among authors: de mol nj. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1241-4. doi: 10.1016/s0960-894x(03)00117-3. Bioorg Med Chem Lett. 2003. PMID: 12657254

4

Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains.

de Mol NJ, Dekker FJ, Broutin I, Fischer MJ, Liskamp RM. de Mol NJ, et al. J Med Chem. 2005 Feb 10;48(3):753-63. doi: 10.1021/jm049359e. J Med Chem. 2005. PMID: 15689159

5

Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2.

de Mol NJ, Catalina MI, Dekker FJ, Fischer MJ, Heck AJ, Liskamp RM. de Mol NJ, et al. Chembiochem. 2005 Dec;6(12):2261-70. doi: 10.1002/cbic.200500141. Chembiochem. 2005. PMID: 16252296

6

Peptidomimetic ligands for the tandem SH2 domain of the Syk protein involved in signal transduction.

Kuil J, van Wandelen LT, de Mol NJ, Liskamp RM. Kuil J, et al. Among authors: de mol nj. Adv Exp Med Biol. 2009;611:81-2. doi: 10.1007/978-0-387-73657-0_36. Adv Exp Med Biol. 2009. PMID: 19400103 No abstract available.

7

Switching between low and high affinity for the Syk tandem SH2 domain by irradiation of azobenzene containing ITAM peptidomimetics.

Kuil J, van Wandelen LT, de Mol NJ, Liskamp RM. Kuil J, et al. Among authors: de mol nj. J Pept Sci. 2009 Oct;15(10):685-91. doi: 10.1002/psc.1173. J Pept Sci. 2009. PMID: 19714714

8

ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain.

Kuil J, Branderhorst HM, Pieters RJ, de Mol NJ, Liskamp RM. Kuil J, et al. Among authors: de mol nj. Org Biomol Chem. 2009 Oct 7;7(19):4088-94. doi: 10.1039/b905938e. Epub 2009 Aug 7. Org Biomol Chem. 2009. PMID: 19763316

9

Cell permeable ITAM constructs for the modulation of mediator release in mast cells.

Kuil J, Fischer MJ, de Mol NJ, Liskamp RM. Kuil J, et al. Among authors: de mol nj. Org Biomol Chem. 2011 Feb 7;9(3):820-33. doi: 10.1039/c0ob00441c. Epub 2010 Nov 25. Org Biomol Chem. 2011. PMID: 21107489

10

Replacement of the intervening amino acid sequence of a Syk-binding diphosphopeptide by a nonpeptide spacer with preservation of high affinity.

Dekker FJ, de Mol NJ, van Ameijde J, Fischer MJ, Ruijtenbeek R, Redegeld FA, Liskamp RM. Dekker FJ, et al. Among authors: de mol nj. Chembiochem. 2002 Mar 1;3(2-3):238-42. doi: 10.1002/1439-7633(20020301)3:2/3<238::AID-CBIC238>3.0.CO;2-W. Chembiochem. 2002. PMID: 11921404 No abstract available.

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