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Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.
Martin EL, Souza DG, Fagundes CT, Amaral FA, Assenzio B, Puntorieri V, Del Sorbo L, Fanelli V, Bosco M, Delsedime L, Pinho JF, Lemos VS, Souto FO, Alves-Filho JC, Cunha FQ, Slutsky AS, Ruckle T, Hirsch E, Teixeira MM, Ranieri VM. Martin EL, et al. Among authors: ruckle t. Am J Respir Crit Care Med. 2010 Sep 15;182(6):762-73. doi: 10.1164/rccm.201001-0088OC. Epub 2010 May 27. Am J Respir Crit Care Med. 2010. PMID: 20508212 Clinical Trial.
Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection.
Maus UA, Backi M, Winter C, Srivastava M, Schwarz MK, Rückle T, Paton JC, Briles D, Mack M, Welte T, Maus R, Bohle RM, Seeger W, Rommel C, Hirsch E, Lohmeyer J, Preissner KT. Maus UA, et al. Among authors: ruckle t. Am J Respir Crit Care Med. 2007 May 1;175(9):958-66. doi: 10.1164/rccm.200610-1533OC. Epub 2007 Feb 22. Am J Respir Crit Care Med. 2007. PMID: 17322108
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.
Fougerat A, Gayral S, Gourdy P, Schambourg A, Rückle T, Schwarz MK, Rommel C, Hirsch E, Arnal JF, Salles JP, Perret B, Breton-Douillon M, Wymann MP, Laffargue M. Fougerat A, et al. Among authors: ruckle t. Circulation. 2008 Mar 11;117(10):1310-7. doi: 10.1161/CIRCULATIONAHA.107.720466. Epub 2008 Feb 11. Circulation. 2008. PMID: 18268153
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, Wymann MP, Hirsch E, Ruckle T, Camps M, Rommel C, Jackson SP, Chilvers ER, Stephens LR, Hawkins PT. Condliffe AM, et al. Among authors: ruckle t. Blood. 2005 Aug 15;106(4):1432-40. doi: 10.1182/blood-2005-03-0944. Epub 2005 May 5. Blood. 2005. PMID: 15878979 Free article.
40 results