Spencer JB - Search Results

1

Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics.

Sun Y, Hong H, Gillies F, Spencer JB, Leadlay PF. Sun Y, et al. Among authors: spencer jb. Chembiochem. 2008 Jan 4;9(1):150-6. doi: 10.1002/cbic.200700492. Chembiochem. 2008. PMID: 18046685

2

A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.

Hong H, Spencer JB, Porter JL, Leadlay PF, Stinear T. Hong H, et al. Among authors: spencer jb. Chembiochem. 2005 Apr;6(4):643-8. doi: 10.1002/cbic.200400339. Chembiochem. 2005. PMID: 15750996 No abstract available.

3

Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin.

Harvey BM, Hong H, Jones MA, Hughes-Thomas ZA, Goss RM, Heathcote ML, Bolanos-Garcia VM, Kroutil W, Staunton J, Leadlay PF, Spencer JB. Harvey BM, et al. Among authors: spencer jb. Chembiochem. 2006 Sep;7(9):1435-42. doi: 10.1002/cbic.200500474. Chembiochem. 2006. PMID: 16897798

4

Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases.

Tran L, Tosin M, Spencer JB, Leadlay PF, Weissman KJ. Tran L, et al. Among authors: spencer jb. Chembiochem. 2008 Apr 14;9(6):905-15. doi: 10.1002/cbic.200700738. Chembiochem. 2008. PMID: 18348128

5

Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic.

Demydchuk Y, Sun Y, Hong H, Staunton J, Spencer JB, Leadlay PF. Demydchuk Y, et al. Among authors: spencer jb. Chembiochem. 2008 May 5;9(7):1136-45. doi: 10.1002/cbic.200700715. Chembiochem. 2008. PMID: 18404760

6

Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure.

Smith L, Hong H, Spencer JB, Leadlay PF. Smith L, et al. Among authors: spencer jb. Chembiochem. 2008 Dec 15;9(18):2967-75. doi: 10.1002/cbic.200800585. Chembiochem. 2008. PMID: 19025863

7

Synthetic chain terminators off-load intermediates from a type I polyketide synthase.

Tosin M, Betancor L, Stephens E, Li WM, Spencer JB, Leadlay PF. Tosin M, et al. Among authors: spencer jb. Chembiochem. 2010 Mar 1;11(4):539-46. doi: 10.1002/cbic.200900772. Chembiochem. 2010. PMID: 20135665

8

Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.

Li TL, Huang F, Haydock SF, Mironenko T, Leadlay PF, Spencer JB. Li TL, et al. Among authors: spencer jb. Chem Biol. 2004 Jan;11(1):107-19. doi: 10.1016/j.chembiol.2004.01.001. Chem Biol. 2004. PMID: 15113000

9

Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.

Hong H, Stinear T, Skelton P, Spencer JB, Leadlay PF. Hong H, et al. Among authors: spencer jb. Chem Commun (Camb). 2005 Sep 14;(34):4306-8. doi: 10.1039/b506835e. Epub 2005 Aug 5. Chem Commun (Camb). 2005. PMID: 16113730

10

Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.

Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF. Siskos AP, et al. Among authors: spencer jb. Chem Biol. 2005 Oct;12(10):1145-53. doi: 10.1016/j.chembiol.2005.08.017. Chem Biol. 2005. PMID: 16242657

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