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Page 1
Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates.
Cicin-Sain L, Messaoudi I, Park B, Currier N, Planer S, Fischer M, Tackitt S, Nikolich-Zugich D, Legasse A, Axthelm MK, Picker LJ, Mori M, Nikolich-Zugich J. Cicin-Sain L, et al. Among authors: legasse a. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19960-5. doi: 10.1073/pnas.0705905104. Epub 2007 Dec 4. Proc Natl Acad Sci U S A. 2007. PMID: 18056811 Free PMC article.
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ. Okoye A, et al. Among authors: legasse a. J Exp Med. 2007 Sep 3;204(9):2171-85. doi: 10.1084/jem.20070567. Epub 2007 Aug 27. J Exp Med. 2007. PMID: 17724130 Free PMC article.
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge.
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, Legasse AW, Axthelm MK, Oswald K, Trubey CM, Piatak M Jr, Lifson JD, Nelson JA, Jarvis MA, Picker LJ. Hansen SG, et al. Among authors: legasse aw. Nat Med. 2009 Mar;15(3):293-9. doi: 10.1038/nm.1935. Epub 2009 Feb 15. Nat Med. 2009. PMID: 19219024 Free PMC article.
Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.
Okoye A, Park H, Rohankhedkar M, Coyne-Johnson L, Lum R, Walker JM, Planer SL, Legasse AW, Sylwester AW, Piatak M Jr, Lifson JD, Sodora DL, Villinger F, Axthelm MK, Schmitz JE, Picker LJ. Okoye A, et al. Among authors: legasse aw. J Exp Med. 2009 Jul 6;206(7):1575-88. doi: 10.1084/jem.20090356. Epub 2009 Jun 22. J Exp Med. 2009. PMID: 19546246 Free PMC article.
Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates.
Cicin-Sain L, Smyk-Pearson S, Currier N, Byrd L, Koudelka C, Robinson T, Swarbrick G, Tackitt S, Legasse A, Fischer M, Nikolich-Zugich D, Park B, Hobbs T, Doane CJ, Mori M, Axthelm MK, Lewinsohn DA, Nikolich-Zugich J. Cicin-Sain L, et al. Among authors: legasse a. J Immunol. 2010 Jun 15;184(12):6739-45. doi: 10.4049/jimmunol.0904193. Epub 2010 May 17. J Immunol. 2010. PMID: 20483749 Free PMC article.
Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.
Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm MK, Villinger F, Piatak M Jr, Lifson JD, Assouline B, Morre M, Picker LJ, Sodora DL. Leone A, et al. Among authors: legasse a. J Immunol. 2010 Aug 1;185(3):1650-9. doi: 10.4049/jimmunol.0902626. Epub 2010 Jul 9. J Immunol. 2010. PMID: 20622118 Free PMC article.
Immune response to the West Nile virus in aged non-human primates.
Wertheimer AM, Uhrlaub JL, Hirsch A, Medigeshi G, Sprague J, Legasse A, Wilk J, Wiley CA, Didier P, Tesh RB, Murray KO, Axthelm MK, Wong SW, Nikolich-Žugich J. Wertheimer AM, et al. Among authors: legasse a. PLoS One. 2010 Dec 2;5(12):e15514. doi: 10.1371/journal.pone.0015514. PLoS One. 2010. PMID: 21151986 Free PMC article.
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine.
Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, Whizin N, Oswald K, Shoemaker R, Swanson T, Legasse AW, Chiuchiolo MJ, Parks CL, Axthelm MK, Nelson JA, Jarvis MA, Piatak M Jr, Lifson JD, Picker LJ. Hansen SG, et al. Among authors: legasse aw. Nature. 2011 May 26;473(7348):523-7. doi: 10.1038/nature10003. Epub 2011 May 11. Nature. 2011. PMID: 21562493 Free PMC article.
59 results