Li J - Search Results

1

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist.

Li J, Isozaki K, Okada K, Matsushima A, Nose T, Costa T, Shimohigashi Y. Li J, et al. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. doi: 10.1016/j.bmc.2007.11.043. Epub 2007 Nov 21. Bioorg Med Chem. 2008. PMID: 18068993

2

Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation.

Okada K, Isozaki K, Li J, Matsushima A, Nose T, Costa T, Shimohigashi Y. Okada K, et al. Among authors: li j. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. doi: 10.1016/j.bmc.2008.09.014. Epub 2008 Sep 9. Bioorg Med Chem. 2008. PMID: 18818087

3

Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation.

Nishimura H, Li J, Isozaki K, Okada K, Matsushima A, Nose T, Costa T, Shimohigashi Y. Nishimura H, et al. Among authors: li j. Bioorg Med Chem. 2009 Aug 1;17(15):5683-7. doi: 10.1016/j.bmc.2009.06.015. Epub 2009 Jun 13. Bioorg Med Chem. 2009. PMID: 19577933

4

Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.

Isozaki K, Li J, Okada K, Nishimura H, Matsushima A, Nose T, Costa T, Shimohigashi Y. Isozaki K, et al. Among authors: li j. Bioorg Med Chem. 2009 Dec 1;17(23):7904-8. doi: 10.1016/j.bmc.2009.10.026. Epub 2009 Oct 30. Bioorg Med Chem. 2009. PMID: 19879767

5

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor.

Inamine S, Nishimura H, Li J, Isozaki K, Matsushima A, Costa T, Shimohigashi Y. Inamine S, et al. Among authors: li j. Bioorg Med Chem. 2014 Nov 1;22(21):5902-9. doi: 10.1016/j.bmc.2014.09.018. Epub 2014 Sep 16. Bioorg Med Chem. 2014. PMID: 25284251

6

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor.

Li J, Nishimura H, Matsushima A, Shimohigashi Y. Li J, et al. Bioorg Med Chem. 2014 Nov 1;22(21):5721-6. doi: 10.1016/j.bmc.2014.09.049. Bioorg Med Chem. 2014. PMID: 25319085

7

Synthesis of amide-type fluoroalkene dipeptide isosteres by an intramolecular redox reaction.

Yamaki Y, Shigenaga A, Li J, Shimohigashi Y, Otaka A. Yamaki Y, et al. Among authors: li j. J Org Chem. 2009 May 1;74(9):3278-85. doi: 10.1021/jo900135t. J Org Chem. 2009. PMID: 19331368

8

Adenovirus-mediated arterial gene transfer does not require prior injury for submaximal gene expression.

Li JJ, Ueno H, Tomita H, Yamamoto H, Kanegae Y, Saito I, Takeshita A. Li JJ, et al. Gene Ther. 1995 Jul;2(5):351-4. Gene Ther. 1995. PMID: 7671111

9

Adenovirus-mediated transfer of cyclin-dependent kinase inhibitor-p21 suppresses neointimal formation in the balloon-injured rat carotid arteries in vivo.

Ueno H, Masuda S, Nishio S, Li JJ, Yamamoto H, Takeshita A. Ueno H, et al. Among authors: li jj. Ann N Y Acad Sci. 1997 Apr 15;811:401-11. doi: 10.1111/j.1749-6632.1997.tb52020.x. Ann N Y Acad Sci. 1997. PMID: 9186616 No abstract available.

10

Quantitative analysis of repeat adenovirus-mediated gene transfer into injured canine femoral arteries.

Ueno H, Li JJ, Tomita H, Yamamoto H, Pan Y, Kanegae Y, Saito I, Takeshita A. Ueno H, et al. Among authors: li jj. Arterioscler Thromb Vasc Biol. 1995 Dec;15(12):2246-53. doi: 10.1161/01.atv.15.12.2246. Arterioscler Thromb Vasc Biol. 1995. PMID: 7489250

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