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Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.
Hamamura K, Tsuji M, Ohkawa Y, Nakashima H, Miyazaki S, Urano T, Yamamoto N, Ueda M, Furukawa K, Furukawa K. Hamamura K, et al. Among authors: urano t. Biochim Biophys Acta. 2008 Mar;1780(3):513-9. doi: 10.1016/j.bbagen.2007.11.002. Epub 2007 Nov 19. Biochim Biophys Acta. 2008. PMID: 18078823
Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.
Hamamura K, Furukawa K, Hayashi T, Hattori T, Nakano J, Nakashima H, Okuda T, Mizutani H, Hattori H, Ueda M, Urano T, Lloyd KO, Furukawa K. Hamamura K, et al. Among authors: urano t. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11041-6. doi: 10.1073/pnas.0503658102. Epub 2005 Jul 22. Proc Natl Acad Sci U S A. 2005. PMID: 16040804 Free PMC article.
Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties.
Nakashima H, Hamamura K, Houjou T, Taguchi R, Yamamoto N, Mitsudo K, Tohnai I, Ueda M, Urano T, Furukawa K, Furukawa K. Nakashima H, et al. Among authors: urano t. Cancer Sci. 2007 Apr;98(4):512-20. doi: 10.1111/j.1349-7006.2007.00419.x. Epub 2007 Jan 31. Cancer Sci. 2007. PMID: 17284246 Free PMC article.
Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.
Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tsuchida A, Okajima T, Furukawa K, Urano T, Furukawa K. Matsumoto Y, et al. Among authors: urano t. J Biol Chem. 2013 Aug 16;288(33):24264-76. doi: 10.1074/jbc.M113.455006. Epub 2013 Jun 27. J Biol Chem. 2013. PMID: 23814067 Free PMC article.
818 results