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Page 1
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.
Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S. Wang H, et al. Among authors: creech k. Mol Endocrinol. 2008 Apr;22(4):838-57. doi: 10.1210/me.2007-0218. Epub 2007 Dec 20. Mol Endocrinol. 2008. PMID: 18096694 Free PMC article.
Identification of a chemical tool for the orphan nuclear receptor FXR.
Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, Plunket KD, Creech KL, Moore LB, Wilson JG, Lewis MC, Jones SA, Willson TM. Maloney PR, et al. Among authors: creech kl. J Med Chem. 2000 Aug 10;43(16):2971-4. doi: 10.1021/jm0002127. J Med Chem. 2000. PMID: 10956205 No abstract available.
Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists.
Smalley TL Jr, Boggs S, Caravella JA, Chen L, Creech KL, Deaton DN, Kaldor I, Parks DJ. Smalley TL Jr, et al. Among authors: creech kl. Bioorg Med Chem Lett. 2015 Jan 15;25(2):280-4. doi: 10.1016/j.bmcl.2014.11.050. Epub 2014 Nov 26. Bioorg Med Chem Lett. 2015. PMID: 25499883
Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans.
Smith SH, Jayawickreme C, Rickard DJ, Nicodeme E, Bui T, Simmons C, Coquery CM, Neil J, Pryor WM, Mayhew D, Rajpal DK, Creech K, Furst S, Lee J, Wu D, Rastinejad F, Willson TM, Viviani F, Morris DC, Moore JT, Cote-Sierra J. Smith SH, et al. Among authors: creech k. J Invest Dermatol. 2017 Oct;137(10):2110-2119. doi: 10.1016/j.jid.2017.05.004. Epub 2017 Jun 6. J Invest Dermatol. 2017. PMID: 28595996 Free article.
Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.
Akwabi-Ameyaw A, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, Miller AB, Navas F 3rd, Parks DJ, Spearing PK, Todd D, Williams SP, Wisely GB. Akwabi-Ameyaw A, et al. Among authors: creech kl. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6154-60. doi: 10.1016/j.bmcl.2011.08.034. Epub 2011 Aug 11. Bioorg Med Chem Lett. 2011. PMID: 21890356
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.
Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, McFadyen RB, Miller AB, Parks DJ, Todd D, Williams SP, Wisely GB. Bass JY, et al. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2969-73. doi: 10.1016/j.bmcl.2009.04.047. Epub 2009 Apr 18. Bioorg Med Chem Lett. 2009. PMID: 19410460
FXR agonist activity of conformationally constrained analogs of GW 4064.
Akwabi-Ameyaw A, Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, McFadyen RB, Miller AB, Navas F 3rd, Parks DJ, Spearing PK, Todd D, Williams SP, Bruce Wisely G. Akwabi-Ameyaw A, et al. Among authors: creech kl. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4733-9. doi: 10.1016/j.bmcl.2009.06.062. Epub 2009 Jun 21. Bioorg Med Chem Lett. 2009. PMID: 19586769
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
Akwabi-Ameyaw A, Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Jones SA, Kaldor I, Liu Y, Madauss KP, Marr HB, McFadyen RB, Miller AB, Navas F III, Parks DJ, Spearing PK, Todd D, Williams SP, Wisely GB. Akwabi-Ameyaw A, et al. Among authors: creech kl. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4339-43. doi: 10.1016/j.bmcl.2008.06.073. Epub 2008 Jun 28. Bioorg Med Chem Lett. 2008. PMID: 18621523
37 results