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Page 1
High-throughput protein crystallography and drug discovery.
Tickle I, Sharff A, Vinkovic M, Yon J, Jhoti H. Tickle I, et al. Among authors: vinkovic m. Chem Soc Rev. 2004 Oct 20;33(8):558-65. doi: 10.1039/b314510g. Epub 2004 Sep 20. Chem Soc Rev. 2004. PMID: 15480479
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.
Howard S, Berdini V, Boulstridge JA, Carr MG, Cross DM, Curry J, Devine LA, Early TR, Fazal L, Gill AL, Heathcote M, Maman S, Matthews JE, McMenamin RL, Navarro EF, O'Brien MA, O'Reilly M, Rees DC, Reule M, Tisi D, Williams G, Vinković M, Wyatt PG. Howard S, et al. Among authors: vinkovic m. J Med Chem. 2009 Jan 22;52(2):379-88. doi: 10.1021/jm800984v. J Med Chem. 2009. PMID: 19143567
Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, Fazal L, Feltell R, Figueroa E, Frederickson M, Lewis J, McMenamin R, Murray CW, O'Brien MA, Parra L, Patel S, Phillips T, Rees DC, Rich S, Smith DM, Trewartha G, Vinkovic M, Williams B, Woolford AJ. Woodhead AJ, et al. Among authors: vinkovic m. J Med Chem. 2010 Aug 26;53(16):5956-69. doi: 10.1021/jm100060b. J Med Chem. 2010. PMID: 20662534
Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.
Saalau-Bethell SM, Berdini V, Cleasby A, Congreve M, Coyle JE, Lock V, Murray CW, O'Brien MA, Rich SJ, Sambrook T, Vinkovic M, Yon JR, Jhoti H. Saalau-Bethell SM, et al. Among authors: vinkovic m. ChemMedChem. 2014 Apr;9(4):823-32. doi: 10.1002/cmdc.201300480. Epub 2014 Feb 24. ChemMedChem. 2014. PMID: 24616449 Free PMC article.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscombe E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor SJ, Hearn K, Hobson S, Holvey RS, Howard S, Jennings CE, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, St Denis JD, Tamanini E, Thomas H, Thompson NT, Vinković M, Wedge SR, Williams PA, Wilsher NE, Zhang B, Zhao Y. Chessari G, et al. Among authors: vinkovic m. J Med Chem. 2021 Apr 8;64(7):4071-4088. doi: 10.1021/acs.jmedchem.0c02188. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33761253
A Diverse Array of Large Capsules Transform in Response to Stimuli.
Wu K, Ronson TK, Goh L, Xue W, Heard AW, Su P, Li X, Vinković M, Nitschke JR. Wu K, et al. Among authors: vinkovic m. J Am Chem Soc. 2023 May 24;145(20):11356-11363. doi: 10.1021/jacs.3c02491. Epub 2023 May 16. J Am Chem Soc. 2023. PMID: 37191451 Free PMC article.
34 results