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Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.
Deng Y, Zhou X, Kugel Desmoulin S, Wu J, Cherian C, Hou Z, Matherly LH, Gangjee A. Deng Y, et al. Among authors: cherian c. J Med Chem. 2009 May 14;52(9):2940-51. doi: 10.1021/jm8011323. J Med Chem. 2009. PMID: 19371039 Free PMC article.
Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.
Desmoulin SK, Wang Y, Wu J, Stout M, Hou Z, Fulterer A, Chang MH, Romero MF, Cherian C, Gangjee A, Matherly LH. Desmoulin SK, et al. Among authors: cherian c. Mol Pharmacol. 2010 Oct;78(4):577-87. doi: 10.1124/mol.110.065896. Epub 2010 Jul 2. Mol Pharmacol. 2010. PMID: 20601456 Free PMC article.
Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter.
Kugel Desmoulin S, Wang L, Hales E, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH. Kugel Desmoulin S, et al. Among authors: cherian c. Mol Pharmacol. 2011 Dec;80(6):1096-107. doi: 10.1124/mol.111.073833. Epub 2011 Sep 22. Mol Pharmacol. 2011. PMID: 21940787 Free PMC article.
Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.
Cherian C, Kugel Desmoulin S, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Gangjee A, Matherly LH. Cherian C, et al. Cancer Chemother Pharmacol. 2013 Apr;71(4):999-1011. doi: 10.1007/s00280-013-2094-0. Epub 2013 Feb 15. Cancer Chemother Pharmacol. 2013. PMID: 23412628 Free PMC article.
69 results