Gust R - Search Results

1

Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan.

Clemenz M, Frost N, Schupp M, Caron S, Foryst-Ludwig A, Böhm C, Hartge M, Gust R, Staels B, Unger T, Kintscher U. Clemenz M, et al. Among authors: gust r. Diabetes. 2008 May;57(5):1405-13. doi: 10.2337/db07-0839. Epub 2008 Jan 9. Diabetes. 2008. PMID: 18184928

2

Characterization of new PPARgamma agonists: analysis of telmisartan's structural components.

Goebel M, Clemenz M, Staels B, Unger T, Kintscher U, Gust R. Goebel M, et al. Among authors: gust r. ChemMedChem. 2009 Mar;4(3):445-56. doi: 10.1002/cmdc.200800285. ChemMedChem. 2009. PMID: 19197922

3

Characterization of new PPARgamma agonists: benzimidazole derivatives - the importance of position 2.

Goebel M, Staels B, Unger T, Kintscher U, Gust R. Goebel M, et al. Among authors: gust r. ChemMedChem. 2009 Jul;4(7):1136-42. doi: 10.1002/cmdc.200900067. ChemMedChem. 2009. PMID: 19504532

4

Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.

Kappert K, Tsuprykov O, Kaufmann J, Fritzsche J, Ott I, Goebel M, Bähr IN, Hässle PL, Gust R, Fleck E, Unger T, Stawowy P, Kintscher U. Kappert K, et al. Among authors: gust r. Hypertension. 2009 Oct;54(4):738-43. doi: 10.1161/HYPERTENSIONAHA.109.132886. Epub 2009 Aug 17. Hypertension. 2009. PMID: 19687349 Clinical Trial.

5

Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode.

Goebel M, Wolber G, Markt P, Staels B, Unger T, Kintscher U, Gust R. Goebel M, et al. Among authors: gust r. Bioorg Med Chem. 2010 Aug 15;18(16):5885-95. doi: 10.1016/j.bmc.2010.06.102. Epub 2010 Jul 3. Bioorg Med Chem. 2010. PMID: 20656494

6

Characterization of telmisartan-derived PPARγ agonists: importance of moiety shift from position 6 to 5 on potency, efficacy and cofactor recruitment.

Herbst L, Goebel M, Bandholtz S, Gust R, Kintscher U. Herbst L, et al. Among authors: gust r. ChemMedChem. 2012 Nov;7(11):1935-42. doi: 10.1002/cmdc.201200337. ChemMedChem. 2012. PMID: 24155042

7

New telmisartan-derived PPARγ agonists: Impact of the 3D-binding mode on the pharmacological profile.

Obermoser V, Urban ME, Murgueitio MS, Wolber G, Kintscher U, Gust R. Obermoser V, et al. Among authors: gust r. Eur J Med Chem. 2016 Nov 29;124:138-152. doi: 10.1016/j.ejmech.2016.08.027. Epub 2016 Aug 15. Eur J Med Chem. 2016. PMID: 27569195

8

Importance of 5/6-aryl substitution on the pharmacological profile of 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived PPARγ agonists.

Obermoser V, Mauersberger R, Schuster D, Czifersky M, Lipova M, Siegl M, Kintscher U, Gust R. Obermoser V, et al. Among authors: gust r. Eur J Med Chem. 2017 Jan 27;126:590-603. doi: 10.1016/j.ejmech.2016.11.051. Epub 2016 Nov 25. Eur J Med Chem. 2017. PMID: 27918994

9

Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren.

Schefe JH, Neumann C, Goebel M, Danser J, Kirsch S, Gust R, Kintscher U, Unger T, Funke-Kaiser H. Schefe JH, et al. Among authors: gust r. J Hypertens. 2008 Sep;26(9):1787-94. doi: 10.1097/HJH.0b013e3283060f2e. J Hypertens. 2008. PMID: 18698213

10

2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation.

Dettmann S, Szymanowitz K, Wellner A, Schiedel A, Müller CE, Gust R. Dettmann S, et al. Among authors: gust r. Bioorg Med Chem. 2010 Jul 15;18(14):4905-16. doi: 10.1016/j.bmc.2010.06.016. Epub 2010 Jun 9. Bioorg Med Chem. 2010. PMID: 20598555

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