Workman P - Search Results

1

An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Banerji U, Sain N, Sharp SY, Valenti M, Asad Y, Ruddle R, Raynaud F, Walton M, Eccles SA, Judson I, Jackman AL, Workman P. Banerji U, et al. Among authors: workman p. Cancer Chemother Pharmacol. 2008 Oct;62(5):769-78. doi: 10.1007/s00280-007-0662-x. Epub 2008 Jan 10. Cancer Chemother Pharmacol. 2008. PMID: 18193424

2

The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.

Walton MI, Sugget N, Workman P. Walton MI, et al. Among authors: workman p. Int J Radiat Oncol Biol Phys. 1992;22(4):643-7. doi: 10.1016/0360-3016(92)90495-4. Int J Radiat Oncol Biol Phys. 1992. PMID: 1544831

3

Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.

Bailey SM, Suggett N, Walton MI, Workman P. Bailey SM, et al. Among authors: workman p. Int J Radiat Oncol Biol Phys. 1992;22(4):649-53. doi: 10.1016/0360-3016(92)90496-5. Int J Radiat Oncol Biol Phys. 1992. PMID: 1544832

4

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.

Walton MI, Wolf CR, Workman P. Walton MI, et al. Among authors: workman p. Biochem Pharmacol. 1992 Jul 22;44(2):251-9. doi: 10.1016/0006-2952(92)90007-6. Biochem Pharmacol. 1992. PMID: 1642640

5

The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.

Walton MI, Smith PJ, Workman P. Walton MI, et al. Among authors: workman p. Cancer Commun. 1991 Jul;3(7):199-206. doi: 10.3727/095535491820873164. Cancer Commun. 1991. PMID: 1714284

6

Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.

Walton MI, Workman P. Walton MI, et al. Among authors: workman p. Biochem Pharmacol. 1990 Jun 1;39(11):1735-42. doi: 10.1016/0006-2952(90)90119-6. Biochem Pharmacol. 1990. PMID: 2344370

7

DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs?

Workman P, Walton MI, Powis G, Schlager JJ. Workman P, et al. Br J Cancer. 1989 Nov;60(5):800-2; discussion 803. doi: 10.1038/bjc.1989.364. Br J Cancer. 1989. PMID: 2508739 Free PMC article. No abstract available.

8

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins.

Walton MI, Wolf CR, Workman P. Walton MI, et al. Among authors: workman p. Int J Radiat Oncol Biol Phys. 1989 Apr;16(4):983-6. doi: 10.1016/0360-3016(89)90900-0. Int J Radiat Oncol Biol Phys. 1989. PMID: 2703406

9

Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice.

Walton MI, Bleehen NM, Workman P. Walton MI, et al. Among authors: workman p. Cancer Res. 1989 May 1;49(9):2351-5. Cancer Res. 1989. PMID: 2706623

10

Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice.

Walton MI, Bleehen NM, Workman P. Walton MI, et al. Among authors: workman p. Br J Cancer. 1989 May;59(5):667-73. doi: 10.1038/bjc.1989.138. Br J Cancer. 1989. PMID: 2736198 Free PMC article.

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