Helfrich W - Search Results

1

Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists.

Bremer E, ten Cate B, Samplonius DF, Mueller N, Wajant H, Stel AJ, Chamuleau M, van de Loosdrecht AA, Stieglmaier J, Fey GH, Helfrich W. Bremer E, et al. Among authors: helfrich w. Cancer Res. 2008 Jan 15;68(2):597-604. doi: 10.1158/0008-5472.CAN-07-5171. Cancer Res. 2008. PMID: 18199557

2

Reduction of EGP-2-positive pulmonary metastases by bispecific-antibody-redirected T cells in an immunocompetent rat model.

Kroesen BJ, Helfrich W, Bakker A, Wubbena AS, Bakker H, Kal HB, The TH, de Leij L. Kroesen BJ, et al. Among authors: helfrich w. Int J Cancer. 1995 Jun 9;61(6):812-8. doi: 10.1002/ijc.2910610612. Int J Cancer. 1995. PMID: 7790116

3

The role of apoptosis in bispecific antibody-mediated T-cell cytotoxicity.

Kroesen BJ, Wellenberg GJ, Bakker A, Helfrich W, The TH, de Leij L. Kroesen BJ, et al. Among authors: helfrich w. Br J Cancer. 1996 Mar;73(6):721-7. doi: 10.1038/bjc.1996.127. Br J Cancer. 1996. PMID: 8611371 Free PMC article.

4

Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2.

Bremer E, Kuijlen J, Samplonius D, Walczak H, de Leij L, Helfrich W. Bremer E, et al. Among authors: helfrich w. Int J Cancer. 2004 Mar 20;109(2):281-90. doi: 10.1002/ijc.11702. Int J Cancer. 2004. PMID: 14750182

5

Exceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells.

Bremer E, Samplonius D, Kroesen BJ, van Genne L, de Leij L, Helfrich W. Bremer E, et al. Among authors: helfrich w. Neoplasia. 2004 Sep-Oct;6(5):636-45. doi: 10.1593/neo.04229. Neoplasia. 2004. PMID: 15548373 Free PMC article.

6

Simultaneous inhibition of epidermal growth factor receptor (EGFR) signaling and enhanced activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated apoptosis induction by an scFv:sTRAIL fusion protein with specificity for human EGFR.

Bremer E, Samplonius DF, van Genne L, Dijkstra MH, Kroesen BJ, de Leij LF, Helfrich W. Bremer E, et al. Among authors: helfrich w. J Biol Chem. 2005 Mar 18;280(11):10025-33. doi: 10.1074/jbc.M413673200. Epub 2005 Jan 11. J Biol Chem. 2005. PMID: 15644326 Free article.

7

Target cell-restricted apoptosis induction of acute leukemic T cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7.

Bremer E, Samplonius DF, Peipp M, van Genne L, Kroesen BJ, Fey GH, Gramatzki M, de Leij LF, Helfrich W. Bremer E, et al. Among authors: helfrich w. Cancer Res. 2005 Apr 15;65(8):3380-8. doi: 10.1158/0008-5472.CAN-04-2756. Cancer Res. 2005. PMID: 15833872

8

CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia.

Bremer E, ten Cate B, Samplonius DF, de Leij LF, Helfrich W. Bremer E, et al. Among authors: helfrich w. Blood. 2006 Apr 1;107(7):2863-70. doi: 10.1182/blood-2005-07-2929. Epub 2005 Dec 6. Blood. 2006. PMID: 16332967 Free article.

9

The efficacy of alginate encapsulated CHO-K1 single chain-TRAIL producer cells in the treatment of brain tumors.

Kuijlen JM, de Haan BJ, Helfrich W, de Boer JF, Samplonius D, Mooij JJ, de Vos P. Kuijlen JM, et al. Among authors: helfrich w. J Neurooncol. 2006 May;78(1):31-9. doi: 10.1007/s11060-005-9071-3. Epub 2006 Apr 6. J Neurooncol. 2006. PMID: 16598433

10

Targeted induction of apoptosis for cancer therapy: current progress and prospects.

Bremer E, van Dam G, Kroesen BJ, de Leij L, Helfrich W. Bremer E, et al. Among authors: helfrich w. Trends Mol Med. 2006 Aug;12(8):382-93. doi: 10.1016/j.molmed.2006.06.002. Epub 2006 Jun 23. Trends Mol Med. 2006. PMID: 16798087 Review.

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