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Page 1
SIRT6 in DNA repair, metabolism and ageing.
Lombard DB, Schwer B, Alt FW, Mostoslavsky R. Lombard DB, et al. J Intern Med. 2008 Feb;263(2):128-41. doi: 10.1111/j.1365-2796.2007.01902.x. J Intern Med. 2008. PMID: 18226091 Free PMC article.
DNA repair, genome stability, and aging.
Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. Lombard DB, et al. Cell. 2005 Feb 25;120(4):497-512. doi: 10.1016/j.cell.2005.01.028. Cell. 2005. PMID: 15734682 Free article. Review.
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. Mostoslavsky R, et al. Among authors: lombard db. Cell. 2006 Jan 27;124(2):315-29. doi: 10.1016/j.cell.2005.11.044. Cell. 2006. PMID: 16439206 Free article.
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Schwer B, et al. Among authors: lombard db. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21790-4. doi: 10.1073/pnas.1016306107. Epub 2010 Nov 22. Proc Natl Acad Sci U S A. 2010. PMID: 21098266 Free PMC article.
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B. Lombard DB, et al. Mol Cell Biol. 2007 Dec;27(24):8807-14. doi: 10.1128/MCB.01636-07. Epub 2007 Oct 8. Mol Cell Biol. 2007. PMID: 17923681 Free PMC article.
Calorie restriction alters mitochondrial protein acetylation.
Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB. Schwer B, et al. Among authors: lombard db. Aging Cell. 2009 Sep;8(5):604-6. doi: 10.1111/j.1474-9726.2009.00503.x. Epub 2009 Jul 9. Aging Cell. 2009. PMID: 19594485 Free PMC article.
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. Sebastián C, et al. Among authors: lombard db. Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047. Cell. 2012. PMID: 23217706 Free PMC article.
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.
Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. Franco S, et al. Among authors: lombard db. Mol Cell. 2006 Jan 20;21(2):201-14. doi: 10.1016/j.molcel.2006.01.005. Mol Cell. 2006. PMID: 16427010 Free article.
103 results