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The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.
Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN, Banks C, Capen A, Goode R, Lewis JE, Sams L, Huss KL, Campbell RM, Iversen PW, Neubauer BL, Brown TJ, Musib L, Geeganage S, Thornton D. Graff JR, et al. Among authors: konicek bw. Cancer Res. 2005 Aug 15;65(16):7462-9. doi: 10.1158/0008-5472.CAN-05-0071. Cancer Res. 2005. PMID: 16103100
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.
Graff JR, Konicek BW, Vincent TM, Lynch RL, Monteith D, Weir SN, Schwier P, Capen A, Goode RL, Dowless MS, Chen Y, Zhang H, Sissons S, Cox K, McNulty AM, Parsons SH, Wang T, Sams L, Geeganage S, Douglass LE, Neubauer BL, Dean NM, Blanchard K, Shou J, Stancato LF, Carter JH, Marcusson EG. Graff JR, et al. Among authors: konicek bw. J Clin Invest. 2007 Sep;117(9):2638-48. doi: 10.1172/JCI32044. J Clin Invest. 2007. PMID: 17786246 Free PMC article.
eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.
Graff JR, Konicek BW, Lynch RL, Dumstorf CA, Dowless MS, McNulty AM, Parsons SH, Brail LH, Colligan BM, Koop JW, Hurst BM, Deddens JA, Neubauer BL, Stancato LF, Carter HW, Douglass LE, Carter JH. Graff JR, et al. Among authors: konicek bw. Cancer Res. 2009 May 1;69(9):3866-73. doi: 10.1158/0008-5472.CAN-08-3472. Epub 2009 Apr 21. Cancer Res. 2009. PMID: 19383915
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases.
Konicek BW, Stephens JR, McNulty AM, Robichaud N, Peery RB, Dumstorf CA, Dowless MS, Iversen PW, Parsons S, Ellis KE, McCann DJ, Pelletier J, Furic L, Yingling JM, Stancato LF, Sonenberg N, Graff JR. Konicek BW, et al. Cancer Res. 2011 Mar 1;71(5):1849-57. doi: 10.1158/0008-5472.CAN-10-3298. Epub 2011 Jan 13. Cancer Res. 2011. PMID: 21233335
29 results