Jacobson KA - Search Results

1

Ligand-specific changes in M3 muscarinic acetylcholine receptor structure detected by a disulfide scanning strategy.

Li JH, Hamdan FF, Kim SK, Jacobson KA, Zhang X, Han SJ, Wess J. Li JH, et al. Among authors: jacobson ka. Biochemistry. 2008 Mar 4;47(9):2776-88. doi: 10.1021/bi7019113. Epub 2008 Feb 5. Biochemistry. 2008. PMID: 18247581

2

A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator delta F508 mutation.

Guay-Broder C, Jacobson KA, Barnoy S, Cabantchik ZI, Guggino WB, Zeitlin PL, Turner RJ, Vergara L, Eidelman O, Pollard HB. Guay-Broder C, et al. Among authors: jacobson ka. Biochemistry. 1995 Jul 18;34(28):9079-87. doi: 10.1021/bi00028a017. Biochemistry. 1995. PMID: 7542476

3

Stimulation by alkylxanthines of chloride efflux in CFPAC-1 cells does not involve A1 adenosine receptors.

Jacobson KA, Guay-Broder C, van Galen PJ, Gallo-Rodriguez C, Melman N, Jacobson MA, Eidelman O, Pollard HB. Jacobson KA, et al. Among authors: jacobson ma. Biochemistry. 1995 Jul 18;34(28):9088-94. doi: 10.1021/bi00028a018. Biochemistry. 1995. PMID: 7542477

4

Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor.

Kim J, Wess J, van Rhee AM, Schöneberg T, Jacobson KA. Kim J, et al. Among authors: jacobson ka. J Biol Chem. 1995 Jun 9;270(23):13987-97. doi: 10.1074/jbc.270.23.13987. J Biol Chem. 1995. PMID: 7775460 Free PMC article.

5

Glutamate residues in the second extracellular loop of the human A2a adenosine receptor are required for ligand recognition.

Kim J, Jiang Q, Glashofer M, Yehle S, Wess J, Jacobson KA. Kim J, et al. Among authors: jacobson ka. Mol Pharmacol. 1996 Apr;49(4):683-91. Mol Pharmacol. 1996. PMID: 8609897 Free PMC article.

6

Hydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognition.

Jiang Q, Van Rhee AM, Kim J, Yehle S, Wess J, Jacobson KA. Jiang Q, et al. Among authors: jacobson ka. Mol Pharmacol. 1996 Sep;50(3):512-21. Mol Pharmacol. 1996. PMID: 8794889 Free PMC article.

7

8-cyclopentyl-1,3-dipropylxanthine and other xanthines differentially bind to the wild-type and delta F508 first nucleotide binding fold (NBF-1) domains of the cystic fibrosis transmembrane conductance regulator.

Cohen BE, Lee G, Jacobson KA, Kim YC, Huang Z, Sorscher EJ, Pollard HB. Cohen BE, et al. Among authors: jacobson ka. Biochemistry. 1997 May 27;36(21):6455-61. doi: 10.1021/bi970150v. Biochemistry. 1997. PMID: 9174362

8

Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.

Moro S, Hoffmann C, Jacobson KA. Moro S, et al. Among authors: jacobson ka. Biochemistry. 1999 Mar 23;38(12):3498-507. doi: 10.1021/bi982369v. Biochemistry. 1999. PMID: 10090736 Free PMC article.

9

Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor.

Gao ZG, Chen A, Barak D, Kim SK, Müller CE, Jacobson KA. Gao ZG, et al. Among authors: jacobson ka. J Biol Chem. 2002 May 24;277(21):19056-63. doi: 10.1074/jbc.M110960200. Epub 2002 Mar 12. J Biol Chem. 2002. PMID: 11891221 Free PMC article.

10

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Gao ZG, Kim SK, Biadatti T, Chen W, Lee K, Barak D, Kim SG, Johnson CR, Jacobson KA. Gao ZG, et al. Among authors: jacobson ka. J Med Chem. 2002 Sep 26;45(20):4471-84. doi: 10.1021/jm020211+. J Med Chem. 2002. PMID: 12238926 Free PMC article.

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