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Germline sequencing in men with metastatic castration-resistant prostate cancer from the BARCODE2 study reveals a wide range of pathogenic variants in DNA repair genes.
Benafif S, Jones AB, Merson S, Rageevakumar R, McGrowder E, Tyler M, Cafferty F, Hogben M, Hussain N, Bancroft E, Reid A, Wakerell S, Karlsson Q, Saunders E, Whitmore I, Sorensen KD, Dennis N, Black E, Wood A, Richards K, Lees K, Perna C, Falconer A, Mills J, Hughes R, Kumar S, Mikropoulos C, Burnett S, Attard G, Hall E, Kote-Jarai Z, Eeles R. Benafif S, et al. Among authors: lees k. BJC Rep. 2024 Feb 15;2(1):15. doi: 10.1038/s44276-023-00024-8. BJC Rep. 2024. PMID: 39516637 Free PMC article.
Normothermic ex vivo kidney perfusion preserves mitochondrial and graft function after warm ischemia and is further enhanced by AP39.
Kawamura M, Parmentier C, Ray S, Clotet-Freixas S, Leung S, John R, Mazilescu L, Nogueira E, Noguchi Y, Goto T, Arulratnam B, Ganesh S, Tamang T, Lees K, Reichman TW, Andreazza AC, Kim PK, Konvalinka A, Selzner M, Robinson LA. Kawamura M, et al. Among authors: lees k. Nat Commun. 2024 Sep 15;15(1):8086. doi: 10.1038/s41467-024-52140-9. Nat Commun. 2024. PMID: 39278958 Free PMC article.
Tenecteplase versus alteplase for thrombolysis in patients selected by use of perfusion imaging within 4·5 h of onset of ischaemic stroke (TASTE): a multicentre, randomised, controlled, phase 3 non-inferiority trial.
Parsons MW, Yogendrakumar V, Churilov L, Garcia-Esperon C, Campbell BCV, Russell ML, Sharma G, Chen C, Lin L, Chew BL, Ng FC, Deepak A, Choi PMC, Kleinig TJ, Cordato DJ, Wu TY, Fink JN, Ma H, Phan TG, Markus HS, Molina CA, Tsai CH, Lee JT, Jeng JS, Strbian D, Meretoja A, Arenillas JF, Buck BH, Devlin MJ, Brown H, Butcher KS, O'Brien B, Sabet A, Wijeratne T, Bivard A, Grimley RS, Agarwal S, Munshi SK, Donnan GA, Davis SM, Miteff F, Spratt NJ, Levi CR; TASTE investigators. Parsons MW, et al. Lancet Neurol. 2024 Aug;23(8):775-786. doi: 10.1016/S1474-4422(24)00206-0. Epub 2024 Jun 13. Lancet Neurol. 2024. PMID: 38880118 Clinical Trial.
676 results