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Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
Ngumbela KC, Day CL, Mncube Z, Nair K, Ramduth D, Thobakgale C, Moodley E, Reddy S, de Pierres C, Mkhwanazi N, Bishop K, van der Stok M, Ismail N, Honeyborne I, Crawford H, Kavanagh DG, Rousseau C, Nickle D, Mullins J, Heckerman D, Korber B, Coovadia H, Kiepiela P, Goulder PJ, Walker BD. Ngumbela KC, et al. Among authors: nickle d. AIDS Res Hum Retroviruses. 2008 Jan;24(1):72-82. doi: 10.1089/aid.2007.0124. AIDS Res Hum Retroviruses. 2008. PMID: 18275350
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
Kiepiela P, Ngumbela K, Thobakgale C, Ramduth D, Honeyborne I, Moodley E, Reddy S, de Pierres C, Mncube Z, Mkhwanazi N, Bishop K, van der Stok M, Nair K, Khan N, Crawford H, Payne R, Leslie A, Prado J, Prendergast A, Frater J, McCarthy N, Brander C, Learn GH, Nickle D, Rousseau C, Coovadia H, Mullins JI, Heckerman D, Walker BD, Goulder P. Kiepiela P, et al. Among authors: nickle d. Nat Med. 2007 Jan;13(1):46-53. doi: 10.1038/nm1520. Epub 2006 Dec 17. Nat Med. 2007. PMID: 17173051
Rare HLA drive additional HIV evolution compared to more frequent alleles.
Rousseau CM, Lockhart DW, Listgarten J, Maley SN, Kadie C, Learn GH, Nickle DC, Heckerman DE, Deng W, Brander C, Ndung'u T, Coovadia H, Goulder PJ, Korber BT, Walker BD, Mullins JI. Rousseau CM, et al. Among authors: nickle dc. AIDS Res Hum Retroviruses. 2009 Mar;25(3):297-303. doi: 10.1089/aid.2008.0208. AIDS Res Hum Retroviruses. 2009. PMID: 19327049 Free PMC article.
Founder effects in the assessment of HIV polymorphisms and HLA allele associations.
Bhattacharya T, Daniels M, Heckerman D, Foley B, Frahm N, Kadie C, Carlson J, Yusim K, McMahon B, Gaschen B, Mallal S, Mullins JI, Nickle DC, Herbeck J, Rousseau C, Learn GH, Miura T, Brander C, Walker B, Korber B. Bhattacharya T, et al. Among authors: nickle dc. Science. 2007 Mar 16;315(5818):1583-6. doi: 10.1126/science.1131528. Science. 2007. PMID: 17363674
HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
Rousseau CM, Daniels MG, Carlson JM, Kadie C, Crawford H, Prendergast A, Matthews P, Payne R, Rolland M, Raugi DN, Maust BS, Learn GH, Nickle DC, Coovadia H, Ndung'u T, Frahm N, Brander C, Walker BD, Goulder PJ, Bhattacharya T, Heckerman DE, Korber BT, Mullins JI. Rousseau CM, et al. Among authors: nickle dc. J Virol. 2008 Jul;82(13):6434-46. doi: 10.1128/JVI.02455-07. Epub 2008 Apr 23. J Virol. 2008. PMID: 18434400 Free PMC article.
129 results