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An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients.
Lin JS, Dauvilliers Y, Arnulf I, Bastuji H, Anaclet C, Parmentier R, Kocher L, Yanagisawa M, Lehert P, Ligneau X, Perrin D, Robert P, Roux M, Lecomte JM, Schwartz JC. Lin JS, et al. Among authors: perrin d. Neurobiol Dis. 2008 Apr;30(1):74-83. doi: 10.1016/j.nbd.2007.12.003. Epub 2007 Dec 27. Neurobiol Dis. 2008. PMID: 18295497 Free article. Clinical Trial.
BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology.
Ligneau X, Perrin D, Landais L, Camelin JC, Calmels TP, Berrebi-Bertrand I, Lecomte JM, Parmentier R, Anaclet C, Lin JS, Bertaina-Anglade V, la Rochelle CD, d'Aniello F, Rouleau A, Gbahou F, Arrang JM, Ganellin CR, Stark H, Schunack W, Schwartz JC. Ligneau X, et al. Among authors: perrin d, d aniello f. J Pharmacol Exp Ther. 2007 Jan;320(1):365-75. doi: 10.1124/jpet.106.111039. Epub 2006 Sep 27. J Pharmacol Exp Ther. 2007. PMID: 17005916
603 results