Jain HD - Search Results

1

Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.

Jain HD, Zhang C, Zhou S, Zhou H, Ma J, Liu X, Liao X, Deveau AM, Dieckhaus CM, Johnson MA, Smith KS, Macdonald TL, Kakeya H, Osada H, Cook JM. Jain HD, et al. Bioorg Med Chem. 2008 Apr 15;16(8):4626-51. doi: 10.1016/j.bmc.2008.02.050. Epub 2008 Feb 20. Bioorg Med Chem. 2008. PMID: 18321710 Free PMC article.

2

Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models.

Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM. Rivas FM, et al. Among authors: jain hd. J Med Chem. 2009 Apr 9;52(7):1795-8. doi: 10.1021/jm801652d. J Med Chem. 2009. PMID: 19275170 Free PMC article.

3

Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.

Gangjee A, Jain HD, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: jain hd. J Med Chem. 2004 Dec 30;47(27):6730-9. doi: 10.1021/jm040144e. J Med Chem. 2004. PMID: 15615522

4

The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.

Gangjee A, Jain HD, Queener SF, Kisliuk RL. Gangjee A, et al. Among authors: jain hd. J Med Chem. 2008 Aug 14;51(15):4589-600. doi: 10.1021/jm800244v. Epub 2008 Jul 8. J Med Chem. 2008. PMID: 18605720 Free PMC article.

5

Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).

Gangjee A, Jain HD, Phan J, Lin X, Song X, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: jain hd. J Med Chem. 2006 Feb 9;49(3):1055-65. doi: 10.1021/jm058276a. J Med Chem. 2006. PMID: 16451071 Free PMC article.

6

Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.

Gangjee A, Jain HD, Kisliuk RL. Gangjee A, et al. Among authors: jain hd. Bioorg Med Chem Lett. 2005 May 2;15(9):2225-30. doi: 10.1016/j.bmcl.2005.03.029. Bioorg Med Chem Lett. 2005. PMID: 15837298

7

2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.

Gangjee A, Jain HD, Phan J, Guo X, Queener SF, Kisliuk RL. Gangjee A, et al. Among authors: jain hd. Bioorg Med Chem. 2010 Jan 15;18(2):953-61. doi: 10.1016/j.bmc.2009.11.029. Epub 2009 Dec 26. Bioorg Med Chem. 2010. PMID: 20056546 Free PMC article.

8

Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II.

Gangjee A, Jain HD, Kurup S. Gangjee A, et al. Among authors: jain hd. Anticancer Agents Med Chem. 2008 Feb;8(2):205-31. doi: 10.2174/187152008783497064. Anticancer Agents Med Chem. 2008. PMID: 18288923 Review.

9

Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I.

Gangjee A, Jain HD, Kurup S. Gangjee A, et al. Among authors: jain hd. Anticancer Agents Med Chem. 2007 Sep;7(5):524-42. doi: 10.2174/187152007781668724. Anticancer Agents Med Chem. 2007. PMID: 17896913 Review.

10

Antifolates -- past, present and future.

Gangjee A, Jain HD. Gangjee A, et al. Among authors: jain hd. Curr Med Chem Anticancer Agents. 2004 Sep;4(5):405-10. doi: 10.2174/1568011043352803. Curr Med Chem Anticancer Agents. 2004. PMID: 15379693 Review.

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