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Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads.
Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A. Tanaka K, et al. Among authors: kobayashi t. J Immunol. 2008 Mar 15;180(6):3746-56. doi: 10.4049/jimmunol.180.6.3746. J Immunol. 2008. PMID: 18322180
Keeping DCs awake by putting SOCS1 to sleep.
Kobayashi T, Yoshimura A. Kobayashi T, et al. Trends Immunol. 2005 Apr;26(4):177-9. doi: 10.1016/j.it.2005.02.004. Trends Immunol. 2005. PMID: 15797506 Review.
Mal-function of TLRs by SOCS.
Kobayashi T, Takaesu G, Yoshimura A. Kobayashi T, et al. Nat Immunol. 2006 Feb;7(2):123-4. doi: 10.1038/ni0206-123. Nat Immunol. 2006. PMID: 16424886 No abstract available.
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