Beaulieu C - Search Results

1

In vivo inhibition of serine protease processing requires a high fractional inhibition of cathepsin C.

Méthot N, Guay D, Rubin J, Ethier D, Ortega K, Wong S, Normandin D, Beaulieu C, Reddy TJ, Riendeau D, Percival MD. Méthot N, et al. Among authors: beaulieu c. Mol Pharmacol. 2008 Jun;73(6):1857-65. doi: 10.1124/mol.108.045682. Epub 2008 Mar 6. Mol Pharmacol. 2008. PMID: 18326050

2

Therapeutic utility and medicinal chemistry of cathepsin C inhibitors.

Guay D, Beaulieu C, Percival MD. Guay D, et al. Among authors: beaulieu c. Curr Top Med Chem. 2010;10(7):708-16. doi: 10.2174/156802610791113469. Curr Top Med Chem. 2010. PMID: 20337582 Review.

3

Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.

Méthot N, Rubin J, Guay D, Beaulieu C, Ethier D, Reddy TJ, Riendeau D, Percival MD. Méthot N, et al. Among authors: beaulieu c. J Biol Chem. 2007 Jul 20;282(29):20836-46. doi: 10.1074/jbc.M702615200. Epub 2007 May 29. J Biol Chem. 2007. PMID: 17535802 Free article.

4

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C.

Guay D, Beaulieu C, Truchon JF, Jagadeeswar Reddy T, Zamboni R, Bayly CI, Methot N, Rubin J, Ethier D, David Percival M. Guay D, et al. Among authors: beaulieu c. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5392-6. doi: 10.1016/j.bmcl.2009.07.114. Epub 2009 Jul 28. Bioorg Med Chem Lett. 2009. PMID: 19665376

5

Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore.

Li L, Beaulieu C, Carriere MC, Denis D, Greig G, Guay D, O'Neill G, Zamboni R, Wang Z. Li L, et al. Among authors: beaulieu c. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7462-5. doi: 10.1016/j.bmcl.2010.10.018. Epub 2010 Oct 12. Bioorg Med Chem Lett. 2010. PMID: 21036609

6

Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.

Beaulieu C, Guay D, Wang Z, Leblanc Y, Roy P, Dufresne C, Zamboni R, Berthelette C, Day S, Tsou N, Denis D, Greig G, Mathieu MC, O'Neill G. Beaulieu C, et al. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2696-700. doi: 10.1016/j.bmcl.2008.03.015. Epub 2008 Mar 10. Bioorg Med Chem Lett. 2008. PMID: 18359630

7

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease.

Beaulieu C, Isabel E, Fortier A, Massé F, Mellon C, Méthot N, Ndao M, Nicoll-Griffith D, Lee D, Park H, Black WC. Beaulieu C, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7444-9. doi: 10.1016/j.bmcl.2010.10.015. Epub 2010 Oct 12. Bioorg Med Chem Lett. 2010. PMID: 21041084

8

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

Gallant M, Beaulieu C, Berthelette C, Colucci J, Crackower MA, Dalton C, Denis D, Ducharme Y, Friesen RW, Guay D, Gervais FG, Hamel M, Houle R, Krawczyk CM, Kosjek B, Lau S, Leblanc Y, Lee EE, Levesque JF, Mellon C, Molinaro C, Mullet W, O'Neill GP, O'Shea P, Sawyer N, Sillaots S, Simard D, Slipetz D, Stocco R, Sørensen D, Truong VL, Wong E, Wu J, Zaghdane H, Wang Z. Gallant M, et al. Among authors: beaulieu c. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. doi: 10.1016/j.bmcl.2010.11.015. Epub 2010 Nov 5. Bioorg Med Chem Lett. 2011. PMID: 21106375

9

Reversible cysteine protease inhibitors show promise for a Chagas disease cure.

Ndao M, Beaulieu C, Black WC, Isabel E, Vasquez-Camargo F, Nath-Chowdhury M, Massé F, Mellon C, Methot N, Nicoll-Griffith DA. Ndao M, et al. Among authors: beaulieu c. Antimicrob Agents Chemother. 2014;58(2):1167-78. doi: 10.1128/AAC.01855-13. Epub 2013 Dec 9. Antimicrob Agents Chemother. 2014. PMID: 24323474 Free PMC article.

10

Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists.

Guay D, Beaulieu C, Belley M, Crane SN, DeLuca J, Gareau Y, Hamel M, Henault M, Hyjazie H, Kargman S, Chan CC, Xu L, Gordon R, Li L, Mamane Y, Morin N, Mancini J, Thérien M, Tranmer G, Truong VL, Wang Z, Black WC. Guay D, et al. Among authors: beaulieu c. Bioorg Med Chem Lett. 2011 May 15;21(10):2832-5. doi: 10.1016/j.bmcl.2011.03.084. Epub 2011 Mar 30. Bioorg Med Chem Lett. 2011. PMID: 21507642

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