Dai Y - Search Results

1

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo.

Hamed H, Hawkins W, Mitchell C, Gilfor D, Zhang G, Pei XY, Dai Y, Hagan MP, Roberts JD, Yacoub A, Grant S, Dent P. Hamed H, et al. Among authors: dai y. Mol Cancer Ther. 2008 Mar;7(3):616-29. doi: 10.1158/1535-7163.MCT-07-2376. Mol Cancer Ther. 2008. PMID: 18347148

2

Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.

Dai Y, Landowski TH, Rosen ST, Dent P, Grant S. Dai Y, et al. Blood. 2002 Nov 1;100(9):3333-43. doi: 10.1182/blood-2002-03-0940. Blood. 2002. PMID: 12384435 Free article.

3

Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.

McKinstry R, Qiao L, Yacoub A, Dai Y, Decker R, Holt S, Hagan MP, Grant S, Dent P. McKinstry R, et al. Among authors: dai y. Cancer Biol Ther. 2002 May-Jun;1(3):243-53. doi: 10.4161/cbt.75. Cancer Biol Ther. 2002. PMID: 12432271 Free article.

4

Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.

Yu C, Dai Y, Dent P, Grant S. Yu C, et al. Among authors: dai y. Cancer Biol Ther. 2002 Nov-Dec;1(6):674-82. doi: 10.4161/cbt.319. Cancer Biol Ther. 2002. PMID: 12642693 Free article.

5

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.

Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, Grant S. Yu C, et al. Among authors: dai y. Cancer Res. 2003 Apr 15;63(8):1822-33. Cancer Res. 2003. PMID: 12702569

6

Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.

Dai Y, Pei XY, Rahmani M, Conrad DH, Dent P, Grant S. Dai Y, et al. Blood. 2004 Apr 1;103(7):2761-70. doi: 10.1182/blood-2003-09-3037. Epub 2003 Nov 26. Blood. 2004. PMID: 14645003 Free article.

7

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.

Dai Y, Dent P, Grant S. Dai Y, et al. Mol Pharmacol. 2003 Dec;64(6):1402-9. doi: 10.1124/mol.64.6.1402. Mol Pharmacol. 2003. PMID: 14645670

8

Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells.

Rosato RR, Almenara JA, Dai Y, Grant S. Rosato RR, et al. Among authors: dai y. Mol Cancer Ther. 2003 Dec;2(12):1273-84. Mol Cancer Ther. 2003. PMID: 14707268

9

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.

Dai Y, Rahmani M, Pei XY, Khanna P, Han SI, Mitchell C, Dent P, Grant S. Dai Y, et al. Blood. 2005 Feb 15;105(4):1706-16. doi: 10.1182/blood-2004-07-2767. Epub 2004 Oct 19. Blood. 2005. PMID: 15494423 Free article.

10

The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.

Pei XY, Dai Y, Grant S. Pei XY, et al. Among authors: dai y. Mol Cancer Ther. 2004 Dec;3(12):1513-24. Mol Cancer Ther. 2004. PMID: 15634644

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