Mian AA - Search Results

1

Targeting of the N-terminal coiled coil oligomerization interface by a helix-2 peptide inhibits unmutated and imatinib-resistant BCR/ABL.

Beissert T, Hundertmark A, Kaburova V, Travaglini L, Mian AA, Nervi C, Ruthardt M. Beissert T, et al. Among authors: mian aa. Int J Cancer. 2008 Jun 15;122(12):2744-52. doi: 10.1002/ijc.23467. Int J Cancer. 2008. PMID: 18366061

2

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I.

Mian AA, Metodieva A, Badura S, Khateb M, Ruimi N, Najajreh Y, Ottmann OG, Mahajna J, Ruthardt M. Mian AA, et al. BMC Cancer. 2012 Sep 17;12:411. doi: 10.1186/1471-2407-12-411. BMC Cancer. 2012. PMID: 22985168 Free PMC article.

3

The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.

Mian AA, Schüll M, Zhao Z, Oancea C, Hundertmark A, Beissert T, Ottmann OG, Ruthardt M. Mian AA, et al. Leukemia. 2009 Sep;23(9):1614-21. doi: 10.1038/leu.2009.69. Epub 2009 Apr 16. Leukemia. 2009. PMID: 19369965

4

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia.

Rafiei A, Mian AA, Döring C, Metodieva A, Oancea C, Thalheimer FB, Hansmann ML, Ottmann OG, Ruthardt M. Rafiei A, et al. Among authors: mian aa. PLoS Genet. 2015 Apr 28;11(4):e1005144. doi: 10.1371/journal.pgen.1005144. eCollection 2015 Apr. PLoS Genet. 2015. PMID: 25919613 Free PMC article.

5

BCR: a new target in resistance mediated by BCR/ABL-315I?

Haberbosch I, Rafiei A, Oancea C, Ottmann GO, Ruthardt M, Mian AA. Haberbosch I, et al. Among authors: mian aa. Genes Cancer. 2016 Jan;7(1-2):36-46. doi: 10.18632/genesandcancer.93. Genes Cancer. 2016. PMID: 27014420 Free PMC article.

6

Oligomerization inhibition, combined with allosteric inhibition, abrogates the transformation potential of T315I-positive BCR/ABL.

Mian AA, Oancea C, Zhao Z, Ottmann OG, Ruthardt M. Mian AA, et al. Leukemia. 2009 Dec;23(12):2242-7. doi: 10.1038/leu.2009.194. Epub 2009 Oct 1. Leukemia. 2009. PMID: 19798092

7

p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia.

Mian AA, Metodieva A, Najajreh Y, Ottmann OG, Mahajna J, Ruthardt M. Mian AA, et al. Haematologica. 2012 Feb;97(2):251-7. doi: 10.3324/haematol.2011.047191. Epub 2011 Nov 4. Haematologica. 2012. PMID: 22058195 Free PMC article.

8

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism.

Khateb M, Ruimi N, Khamisie H, Najajreh Y, Mian A, Metodieva A, Ruthardt M, Mahajna J. Khateb M, et al. BMC Cancer. 2012 Nov 27;12:563. doi: 10.1186/1471-2407-12-563. BMC Cancer. 2012. PMID: 23186157 Free PMC article.

9

PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation.

Mian AA, Rafiei A, Haberbosch I, Zeifman A, Titov I, Stroylov V, Metodieva A, Stroganov O, Novikov F, Brill B, Chilov G, Hoelzer D, Ottmann OG, Ruthardt M. Mian AA, et al. Leukemia. 2015 May;29(5):1104-14. doi: 10.1038/leu.2014.326. Epub 2014 Nov 14. Leukemia. 2015. PMID: 25394714

10

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1^T315I and BCR-ABL1^T315I-E255K.

Mian AA, Haberbosch I, Khamaisie H, Agbarya A, Pietsch L, Eshel E, Najib D, Chiriches C, Ottmann OG, Hantschel O, Biondi RM, Ruthardt M, Mahajna J. Mian AA, et al. Ann Hematol. 2021 Aug;100(8):2023-2029. doi: 10.1007/s00277-020-04357-z. Epub 2021 Jun 10. Ann Hematol. 2021. PMID: 34110462 Free PMC article.

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