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A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme.
Zhang Z, Zariwala MA, Mahadevan MM, Caballero-Campo P, Shen X, Escudier E, Duriez B, Bridoux AM, Leigh M, Gerton GL, Kennedy M, Amselem S, Knowles MR, Strauss JF 3rd. Zhang Z, et al. Among authors: shen x. Biol Reprod. 2007 Nov;77(5):864-71. doi: 10.1095/biolreprod.107.063206. Epub 2007 Aug 15. Biol Reprod. 2007. PMID: 17699735
MEIG1 is essential for spermiogenesis in mice.
Zhang Z, Shen X, Gude DR, Wilkinson BM, Justice MJ, Flickinger CJ, Herr JC, Eddy EM, Strauss JF 3rd. Zhang Z, et al. Among authors: shen x. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17055-60. doi: 10.1073/pnas.0906414106. Epub 2009 Sep 17. Proc Natl Acad Sci U S A. 2009. PMID: 19805151 Free PMC article.
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