Anderson EM - Search Results

1

Experimental validation of the importance of seed complement frequency to siRNA specificity.

Anderson EM, Birmingham A, Baskerville S, Reynolds A, Maksimova E, Leake D, Fedorov Y, Karpilow J, Khvorova A. Anderson EM, et al. RNA. 2008 May;14(5):853-61. doi: 10.1261/rna.704708. Epub 2008 Mar 26. RNA. 2008. PMID: 18367722 Free PMC article.

2

Different delivery methods-different expression profiles.

Fedorov Y, King A, Anderson E, Karpilow J, Ilsley D, Marshall W, Khvorova A. Fedorov Y, et al. Nat Methods. 2005 Apr;2(4):241. doi: 10.1038/nmeth0405-241. Nat Methods. 2005. PMID: 15782213 No abstract available.

3

Gene profiling study of G3139- and Bcl-2-targeting siRNAs identifies a unique G3139 molecular signature.

Anderson EM, Miller P, Ilsley D, Marshall W, Khvorova A, Stein CA, Benimetskaya L. Anderson EM, et al. Cancer Gene Ther. 2006 Apr;13(4):406-14. doi: 10.1038/sj.cgt.7700901. Cancer Gene Ther. 2006. PMID: 16195754

4

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets.

Birmingham A, Anderson EM, Reynolds A, Ilsley-Tyree D, Leake D, Fedorov Y, Baskerville S, Maksimova E, Robinson K, Karpilow J, Marshall WS, Khvorova A. Birmingham A, et al. Among authors: anderson em. Nat Methods. 2006 Mar;3(3):199-204. doi: 10.1038/nmeth854. Nat Methods. 2006. PMID: 16489337

5

Induction of the interferon response by siRNA is cell type- and duplex length-dependent.

Reynolds A, Anderson EM, Vermeulen A, Fedorov Y, Robinson K, Leake D, Karpilow J, Marshall WS, Khvorova A. Reynolds A, et al. Among authors: anderson em. RNA. 2006 Jun;12(6):988-93. doi: 10.1261/rna.2340906. Epub 2006 Apr 12. RNA. 2006. PMID: 16611941 Free PMC article.

6

Off-target effects by siRNA can induce toxic phenotype.

Fedorov Y, Anderson EM, Birmingham A, Reynolds A, Karpilow J, Robinson K, Leake D, Marshall WS, Khvorova A. Fedorov Y, et al. Among authors: anderson em. RNA. 2006 Jul;12(7):1188-96. doi: 10.1261/rna.28106. Epub 2006 May 8. RNA. 2006. PMID: 16682561 Free PMC article.

7

A protocol for designing siRNAs with high functionality and specificity.

Birmingham A, Anderson E, Sullivan K, Reynolds A, Boese Q, Leake D, Karpilow J, Khvorova A. Birmingham A, et al. Nat Protoc. 2007;2(9):2068-78. doi: 10.1038/nprot.2007.278. Nat Protoc. 2007. PMID: 17853862

8

Identifying siRNA-induced off-targets by microarray analysis.

Anderson E, Boese Q, Khvorova A, Karpilow J. Anderson E, et al. Methods Mol Biol. 2008;442:45-63. doi: 10.1007/978-1-59745-191-8_4. Methods Mol Biol. 2008. PMID: 18369777

9

Targeted gene editing by transfection of in vitro reconstituted Streptococcus thermophilus Cas9 nuclease complex.

Glemzaite M, Balciunaite E, Karvelis T, Gasiunas G, Grusyte MM, Alzbutas G, Jurcyte A, Anderson EM, Maksimova E, Smith AJ, Lubys A, Zaliauskiene L, Siksnys V. Glemzaite M, et al. Among authors: anderson em. RNA Biol. 2015;12(1):1-4. doi: 10.1080/15476286.2015.1017209. RNA Biol. 2015. PMID: 25826410 Free PMC article. No abstract available.

10

Systematic analysis of CRISPR-Cas9 mismatch tolerance reveals low levels of off-target activity.

Anderson EM, Haupt A, Schiel JA, Chou E, Machado HB, Strezoska Ž, Lenger S, McClelland S, Birmingham A, Vermeulen A, Smith Av. Anderson EM, et al. J Biotechnol. 2015 Oct 10;211:56-65. doi: 10.1016/j.jbiotec.2015.06.427. Epub 2015 Jul 17. J Biotechnol. 2015. PMID: 26189696 Free article.

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