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Page 1
An epoxidation mechanism of carbamazepine by CYP3A4.
Hata M, Tanaka Y, Kyoda N, Osakabe T, Yuki H, Ishii I, Kitada M, Neya S, Hoshino T. Hata M, et al. Among authors: tanaka y. Bioorg Med Chem. 2008 May 1;16(9):5134-48. doi: 10.1016/j.bmc.2008.03.023. Epub 2008 Mar 10. Bioorg Med Chem. 2008. PMID: 18372180
Substrate deacylation mechanisms of serine-beta-lactamases.
Hata M, Fujii Y, Tanaka Y, Ishikawa H, Ishii M, Neya S, Tsuda M, Hoshino T. Hata M, et al. Among authors: tanaka y. Biol Pharm Bull. 2006 Nov;29(11):2151-9. doi: 10.1248/bpb.29.2151. Biol Pharm Bull. 2006. PMID: 17077507 Free article. Review.
Conformational restriction approach to β-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
Yonezawa S, Fujiwara K, Yamamoto T, Hattori K, Yamakawa H, Muto C, Hosono M, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: tanaka y. Bioorg Med Chem. 2013 Nov 1;21(21):6506-22. doi: 10.1016/j.bmc.2013.08.036. Epub 2013 Aug 28. Bioorg Med Chem. 2013. PMID: 24051074
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.
Yonezawa S, Yamakawa H, Muto C, Hosono M, Yamamoto T, Hattori K, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: tanaka y. Bioorg Med Chem Lett. 2013 May 15;23(10):2912-5. doi: 10.1016/j.bmcl.2013.03.056. Epub 2013 Mar 26. Bioorg Med Chem Lett. 2013. PMID: 23562056
Conformational restriction approach to β-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
Yonezawa S, Yamamoto T, Yamakawa H, Muto C, Hosono M, Hattori K, Higashino K, Yutsudo T, Iwamoto H, Kondo Y, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: tanaka y. J Med Chem. 2012 Oct 25;55(20):8838-58. doi: 10.1021/jm3011405. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998419
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening.
Tobinaga H, Kameyama T, Oohara M, Kobayashi N, Ohdan M, Ishizuka N, Kume M, Tomari M, Tanaka Y, Takahashi F, Kinoshita H, Shimada S, Shinohara S, Kai H. Tobinaga H, et al. Among authors: tanaka y. Bioorg Med Chem Lett. 2018 Jul 15;28(13):2338-2342. doi: 10.1016/j.bmcl.2017.04.060. Epub 2017 Apr 19. Bioorg Med Chem Lett. 2018. PMID: 29805055
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives.
Tobinaga H, Kameyama T, Asahi K, Horiguchi T, Oohara M, Taoda Y, Hata K, Hasegawa T, Tada Y, Kurihara N, Kanda Y, Yagi S, Tomari M, Tanaka Y, Takahashi F, Taniguchi E, Takahara Y, Shimada S, Takeyama C, Yamamoto S, Shinohara S, Kai H. Tobinaga H, et al. Among authors: tanaka y. Bioorg Med Chem Lett. 2020 Dec 15;30(24):127636. doi: 10.1016/j.bmcl.2020.127636. Epub 2020 Oct 22. Bioorg Med Chem Lett. 2020. PMID: 33132115
Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa.
Takeoka Y, Tanino T, Sekiguchi M, Yonezawa S, Sakagami M, Takahashi F, Togame H, Tanaka Y, Takemoto H, Ichikawa S, Matsuda A. Takeoka Y, et al. Among authors: tanaka y. ACS Med Chem Lett. 2014 Mar 6;5(5):556-60. doi: 10.1021/ml5000096. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900879 Free PMC article.
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