Heise C - Search Results

1

A phase I pharmacokinetic and pharmacodynamic study of TKI258, an oral, multitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumors.

Sarker D, Molife R, Evans TR, Hardie M, Marriott C, Butzberger-Zimmerli P, Morrison R, Fox JA, Heise C, Louie S, Aziz N, Garzon F, Michelson G, Judson IR, Jadayel D, Braendle E, de Bono JS. Sarker D, et al. Among authors: heise c. Clin Cancer Res. 2008 Apr 1;14(7):2075-81. doi: 10.1158/1078-0432.CCR-07-1466. Clin Cancer Res. 2008. PMID: 18381947 Free article. Clinical Trial.

2

CHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia.

Lopes de Menezes DE, Peng J, Garrett EN, Louie SG, Lee SH, Wiesmann M, Tang Y, Shephard L, Goldbeck C, Oei Y, Ye H, Aukerman SL, Heise C. Lopes de Menezes DE, et al. Among authors: heise c. Clin Cancer Res. 2005 Jul 15;11(14):5281-91. doi: 10.1158/1078-0432.CCR-05-0358. Clin Cancer Res. 2005. PMID: 16033847

3

A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer.

Ganly I, Kirn D, Eckhardt G, Rodriguez GI, Soutar DS, Otto R, Robertson AG, Park O, Gulley ML, Heise C, Von Hoff DD, Kaye SB. Ganly I, et al. Among authors: heise c. Clin Cancer Res. 2000 Mar;6(3):798-806. Clin Cancer Res. 2000. PMID: 10741699 Clinical Trial.

4

In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models.

Lee SH, Lopes de Menezes D, Vora J, Harris A, Ye H, Nordahl L, Garrett E, Samara E, Aukerman SL, Gelb AB, Heise C. Lee SH, et al. Among authors: heise c. Clin Cancer Res. 2005 May 15;11(10):3633-41. doi: 10.1158/1078-0432.CCR-04-2129. Clin Cancer Res. 2005. PMID: 15897558

5

CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice.

Xin X, Abrams TJ, Hollenbach PW, Rendahl KG, Tang Y, Oei YA, Embry MG, Swinarski DE, Garrett EN, Pryer NK, Trudel S, Jallal B, Mendel DB, Heise CC. Xin X, et al. Among authors: heise cc. Clin Cancer Res. 2006 Aug 15;12(16):4908-15. doi: 10.1158/1078-0432.CCR-06-0957. Clin Cancer Res. 2006. PMID: 16914579

6

SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial.

Hidalgo M, Plaza C, Musteanu M, Illei P, Brachmann CB, Heise C, Pierce D, Lopez-Casas PP, Menendez C, Tabernero J, Romano A, Wei X, Lopez-Rios F, Von Hoff DD. Hidalgo M, et al. Among authors: heise c. Clin Cancer Res. 2015 Nov 1;21(21):4811-8. doi: 10.1158/1078-0432.CCR-14-3222. Epub 2015 Jul 13. Clin Cancer Res. 2015. PMID: 26169969 Clinical Trial.

7

CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.

Trudel S, Li ZH, Wei E, Wiesmann M, Chang H, Chen C, Reece D, Heise C, Stewart AK. Trudel S, et al. Among authors: heise c. Blood. 2005 Apr 1;105(7):2941-8. doi: 10.1182/blood-2004-10-3913. Epub 2004 Dec 14. Blood. 2005. PMID: 15598814 Free article.

8

Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints.

Reid T, Galanis E, Abbruzzese J, Sze D, Wein LM, Andrews J, Randlev B, Heise C, Uprichard M, Hatfield M, Rome L, Rubin J, Kirn D. Reid T, et al. Among authors: heise c. Cancer Res. 2002 Nov 1;62(21):6070-9. Cancer Res. 2002. PMID: 12414631 Clinical Trial.

9

Efficacy with a replication-selective adenovirus plus cisplatin-based chemotherapy: dependence on sequencing but not p53 functional status or route of administration.

Heise C, Lemmon M, Kirn D. Heise C, et al. Clin Cancer Res. 2000 Dec;6(12):4908-14. Clin Cancer Res. 2000. PMID: 11156251

10

Increased cellular accumulation and distribution of amrubicin contribute to its activity in anthracycline-resistant cancer cells.

Mamidipudi V, Shi T, Brady H, Surapaneni S, Chopra R, Aukerman SL, Heise C, Sung V. Mamidipudi V, et al. Among authors: heise c. Cancer Chemother Pharmacol. 2012 Apr;69(4):965-76. doi: 10.1007/s00280-011-1782-x. Epub 2011 Nov 26. Cancer Chemother Pharmacol. 2012. PMID: 22120960

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