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Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.
Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, Sette A, Walker BD, Allen TM. Schneidewind A, et al. Among authors: chen h. J Virol. 2008 Jun;82(11):5594-605. doi: 10.1128/JVI.02356-07. Epub 2008 Apr 2. J Virol. 2008. PMID: 18385228 Free PMC article.
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra F, Yu XG, Douek DC, Kaufmann DE, Allen TM, Walker BD. Chen H, et al. Nat Immunol. 2012 Jun 10;13(7):691-700. doi: 10.1038/ni.2342. Nat Immunol. 2012. PMID: 22683743 Free PMC article.
HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.
Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJR. Leitman EM, et al. Among authors: chen f, chen h. J Virol. 2017 Oct 27;91(22):e00544-17. doi: 10.1128/JVI.00544-17. Print 2017 Nov 15. J Virol. 2017. PMID: 28878089 Free PMC article. Clinical Trial.
Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals.
Zhang SC, Martin E, Shimada M, Godfrey SB, Fricke J, Locastro S, Lai NY, Liebesny P, Carlson JM, Brumme CJ, Ogbechie OA, Chen H, Walker BD, Brumme ZL, Kavanagh DG, Le Gall S. Zhang SC, et al. Among authors: chen h. J Immunol. 2012 Jun 15;188(12):5924-34. doi: 10.4049/jimmunol.1200219. Epub 2012 May 14. J Immunol. 2012. PMID: 22586036 Free PMC article.
T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable.
Joglekar AV, Liu Z, Weber JK, Ouyang Y, Jeppson JD, Noh WJ, Lamothe-Molina PA, Chen H, Kang SG, Bethune MT, Zhou R, Walker BD, Baltimore D. Joglekar AV, et al. Among authors: chen h. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1877-1882. doi: 10.1073/pnas.1718659115. Epub 2018 Feb 7. Proc Natl Acad Sci U S A. 2018. PMID: 29437954 Free PMC article.
CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21.
Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, Brass AL, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. Chen H, et al. J Clin Invest. 2011 Apr;121(4):1549-60. doi: 10.1172/JCI44539. Epub 2011 Mar 14. J Clin Invest. 2011. PMID: 21403397 Free PMC article.
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