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Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3.
Puri V, McQuillin A, Datta S, Choudhury K, Pimm J, Thirumalai S, Krasucki R, Lawrence J, Quested D, Bass N, Crombie C, Fraser G, Walker N, Moorey H, Ray MK, Sule A, Curtis D, St Clair D, Gurling H. Puri V, et al. Among authors: gurling h. Eur J Hum Genet. 2008 Oct;16(10):1275-82. doi: 10.1038/ejhg.2008.76. Epub 2008 Apr 16. Eur J Hum Genet. 2008. PMID: 18414510
Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q.
Curtis D, Kalsi G, Brynjolfsson J, McInnis M, O'Neill J, Smyth C, Moloney E, Murphy P, McQuillin A, Petursson H, Gurling H. Curtis D, et al. Among authors: gurling h. Psychiatr Genet. 2003 Jun;13(2):77-84. doi: 10.1097/01.ypg.0000056684.89558.d2. Psychiatr Genet. 2003. PMID: 12782963
The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia.
Pimm J, McQuillin A, Thirumalai S, Lawrence J, Quested D, Bass N, Lamb G, Moorey H, Datta SR, Kalsi G, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Curtis D, Gurling H. Pimm J, et al. Among authors: gurling h. Am J Hum Genet. 2005 May;76(5):902-7. doi: 10.1086/430095. Epub 2005 Mar 25. Am J Hum Genet. 2005. PMID: 15793701 Free PMC article.
Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4).
Rizig MA, McQuillin A, Puri V, Choudhury K, Datta S, Thirumalai S, Lawrence J, Quested D, Pimm J, Bass N, Lamb G, Moorey H, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Kandasami G, Curtis D, Gurling H. Rizig MA, et al. Among authors: gurling h. Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 5;141B(3):296-300. doi: 10.1002/ajmg.b.30288. Am J Med Genet B Neuropsychiatr Genet. 2006. PMID: 16508931
Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene.
Puri V, McQuillin A, Choudhury K, Datta S, Pimm J, Thirumalai S, Krasucki R, Lawrence J, Quested D, Bass N, Moorey H, Morgan J, Punukollu B, Kandasami G, Curtis D, Gurling H. Puri V, et al. Among authors: gurling h. Biol Psychiatry. 2007 Apr 1;61(7):873-9. doi: 10.1016/j.biopsych.2006.06.014. Epub 2006 Sep 15. Biol Psychiatry. 2007. PMID: 16978587
Identification of the Slynar gene (AY070435) and related brain expressed sequences as a candidate gene for susceptibility to affective disorders through allelic and haplotypic association with bipolar disorder on chromosome 12q24.
Kalsi G, McQuillin A, Degn B, Lundorf MD, Bass NJ, Lawrence J, Choudhury K, Puri V, Nyegaard M, Curtis D, Mors O, Kruse T, Kerwin S, Gurling H. Kalsi G, et al. Among authors: gurling h. Am J Psychiatry. 2006 Oct;163(10):1767-76. doi: 10.1176/ajp.2006.163.10.1767. Am J Psychiatry. 2006. PMID: 17012688
270 results