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Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.
O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X. O'Callaghan P, et al. Among authors: van kuppevelt th. Brain Pathol. 2008 Oct;18(4):548-61. doi: 10.1111/j.1750-3639.2008.00152.x. Epub 2008 Apr 11. Brain Pathol. 2008. PMID: 18422760 Free PMC article.
The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.
Smits NC, Kurup S, Rops AL, ten Dam GB, Massuger LF, Hafmans T, Turnbull JE, Spillmann D, Li JP, Kennel SJ, Wall JS, Shworak NW, Dekhuijzen PN, van der Vlag J, van Kuppevelt TH. Smits NC, et al. Among authors: van kuppevelt th, van der vlag j. J Biol Chem. 2010 Dec 24;285(52):41143-51. doi: 10.1074/jbc.M110.153791. Epub 2010 Sep 13. J Biol Chem. 2010. PMID: 20837479 Free PMC article.
Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid ß plaques of Alzheimer's disease: evidence from mouse models and patients.
Hosono-Fukao T, Ohtake-Niimi S, Hoshino H, Britschgi M, Akatsu H, Hossain MM, Nishitsuji K, van Kuppevelt TH, Kimata K, Michikawa M, Wyss-Coray T, Uchimura K. Hosono-Fukao T, et al. Among authors: van kuppevelt th. Am J Pathol. 2012 May;180(5):2056-67. doi: 10.1016/j.ajpath.2012.01.015. Epub 2012 Mar 17. Am J Pathol. 2012. PMID: 22429964
Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.
Garsen M, Benner M, Dijkman HB, van Kuppevelt TH, Li JP, Rabelink TJ, Vlodavsky I, Berden JH, Rops AL, Elkin M, van der Vlag J. Garsen M, et al. Among authors: van kuppevelt th, van der vlag j. Am J Pathol. 2016 Apr;186(4):805-15. doi: 10.1016/j.ajpath.2015.12.008. Epub 2016 Feb 9. Am J Pathol. 2016. PMID: 26873445 Free article.
Epigenetic Targeting of Heparan Sulfate 3-O- and 6-O-Sulfation in Breast Cancer Cells: Prospects for Attenuating Prothrombotic Tumor Cell Activities.
Bückreiß N, Schulz-Fincke M, König P, Maccarana M, van Kuppevelt TH, Li JP, Götte M, Bendas G. Bückreiß N, et al. Among authors: van kuppevelt th. ACS Pharmacol Transl Sci. 2024 Jul 30;7(8):2484-2495. doi: 10.1021/acsptsci.4c00295. eCollection 2024 Aug 9. ACS Pharmacol Transl Sci. 2024. PMID: 39144559
370 results