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The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression.
Radtke S, Haan S, Jörissen A, Hermanns HM, Diefenbach S, Smyczek T, Schmitz-Vandeleur H, Heinrich PC, Behrmann I, Haan C. Radtke S, et al. Among authors: heinrich pc. J Biol Chem. 2005 Jul 8;280(27):25760-8. doi: 10.1074/jbc.M500822200. Epub 2005 May 12. J Biol Chem. 2005. PMID: 15894543 Free article.
335 results