He GX - Search Results

1

Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.

Birkus G, Kutty N, He GX, Mulato A, Lee W, McDermott M, Cihlar T. Birkus G, et al. Among authors: he gx. Mol Pharmacol. 2008 Jul;74(1):92-100. doi: 10.1124/mol.108.045526. Epub 2008 Apr 22. Mol Pharmacol. 2008. PMID: 18430788

2

Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.

Lee WA, He GX, Eisenberg E, Cihlar T, Swaminathan S, Mulato A, Cundy KC. Lee WA, et al. Among authors: he gx. Antimicrob Agents Chemother. 2005 May;49(5):1898-906. doi: 10.1128/AAC.49.5.1898-1906.2005. Antimicrob Agents Chemother. 2005. PMID: 15855512 Free PMC article.

3

Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.

Cihlar T, He GX, Liu X, Chen JM, Hatada M, Swaminathan S, McDermott MJ, Yang ZY, Mulato AS, Chen X, Leavitt SA, Stray KM, Lee WA. Cihlar T, et al. Among authors: he gx. J Mol Biol. 2006 Oct 27;363(3):635-47. doi: 10.1016/j.jmb.2006.07.073. Epub 2006 Aug 2. J Mol Biol. 2006. PMID: 16979654

4

In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile.

Callebaut C, Stray K, Tsai L, Williams M, Yang ZY, Cannizzaro C, Leavitt SA, Liu X, Wang K, Murray BP, Mulato A, Hatada M, Priskich T, Parkin N, Swaminathan S, Lee W, He GX, Xu L, Cihlar T. Callebaut C, et al. Among authors: he gx. Antimicrob Agents Chemother. 2011 Apr;55(4):1366-76. doi: 10.1128/AAC.01183-10. Epub 2011 Jan 18. Antimicrob Agents Chemother. 2011. PMID: 21245449 Free PMC article.

5

Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood.

Eisenberg EJ, He GX, Lee WA. Eisenberg EJ, et al. Among authors: he gx. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1091-8. doi: 10.1081/NCN-100002496. Nucleosides Nucleotides Nucleic Acids. 2001. PMID: 11562963

6

N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Mitchell ML, Son JC, Guo H, Im YA, Cho EJ, Wang J, Hayes J, Wang M, Paul A, Lansdon EB, Chen JM, Graupe D, Rhodes G, He GX, Geleziunas R, Xu L, Kim CU. Mitchell ML, et al. Among authors: he gx. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1589-92. doi: 10.1016/j.bmcl.2010.01.085. Epub 2010 Jan 21. Bioorg Med Chem Lett. 2010. PMID: 20138513

7

N2- and C8-substituted oligodeoxynucleotides with enhanced thrombin inhibitory activity in vitro and in vivo.

He GX, Krawczyk SH, Swaminathan S, Shea RG, Dougherty JP, Terhorst T, Law VS, Griffin LC, Coutré S, Bischofberger N. He GX, et al. J Med Chem. 1998 Jun 18;41(13):2234-42. doi: 10.1021/jm970434d. J Med Chem. 1998. PMID: 9632356

8

Effect of hydrogen peroxide on the viscosity of a hydroxyethylcellulose-based gel.

Dahl T, He GX, Samuels G. Dahl T, et al. Among authors: he gx. Pharm Res. 1998 Jul;15(7):1137-40. doi: 10.1023/a:1011958901154. Pharm Res. 1998. PMID: 9688072 No abstract available.

9

In vitro and in vivo activities of oligodeoxynucleotide-based thrombin inhibitors containing neutral formacetal linkages.

He GX, Williams JP, Postich MJ, Swaminathan S, Shea RG, Terhorst T, Law VS, Mao CT, Sueoka C, Coutré S, Bischofberger N. He GX, et al. J Med Chem. 1998 Oct 22;41(22):4224-31. doi: 10.1021/jm970766i. J Med Chem. 1998. PMID: 9784097

10

Improved high-performance liquid chromatographic method for analysis of L-carnitine in pharmaceutical formulations.

He GX, Dahl T. He GX, et al. J Pharm Biomed Anal. 2000 Aug 15;23(2-3):315-21. doi: 10.1016/s0731-7085(00)00249-1. J Pharm Biomed Anal. 2000. PMID: 10933524

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