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Molecular determinants of species-specific activation or blockade of TRPA1 channels.
Chen J, Zhang XF, Kort ME, Huth JR, Sun C, Miesbauer LJ, Cassar SC, Neelands T, Scott VE, Moreland RB, Reilly RM, Hajduk PJ, Kym PR, Hutchins CW, Faltynek CR. Chen J, et al. Among authors: kym pr. J Neurosci. 2008 May 7;28(19):5063-71. doi: 10.1523/JNEUROSCI.0047-08.2008. J Neurosci. 2008. PMID: 18463259 Free PMC article.
Pore dilation occurs in TRPA1 but not in TRPM8 channels.
Chen J, Kim D, Bianchi BR, Cavanaugh EJ, Faltynek CR, Kym PR, Reilly RM. Chen J, et al. Among authors: kym pr. Mol Pain. 2009 Jan 21;5:3. doi: 10.1186/1744-8069-5-3. Mol Pain. 2009. PMID: 19159452 Free PMC article.
TRPA1: the species difference.
Chen J, Kym PR. Chen J, et al. Among authors: kym pr. J Gen Physiol. 2009 Jun;133(6):623-5. doi: 10.1085/jgp.200910246. J Gen Physiol. 2009. PMID: 19468076 Free PMC article. No abstract available.
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Chen J, Joshi SK, DiDomenico S, Perner RJ, Mikusa JP, Gauvin DM, Segreti JA, Han P, Zhang XF, Niforatos W, Bianchi BR, Baker SJ, Zhong C, Simler GH, McDonald HA, Schmidt RG, McGaraughty SP, Chu KL, Faltynek CR, Kort ME, Reilly RM, Kym PR. Chen J, et al. Among authors: kym pr. Pain. 2011 May;152(5):1165-1172. doi: 10.1016/j.pain.2011.01.049. Epub 2011 Mar 12. Pain. 2011. PMID: 21402443
Analgesic potential of TRPV1 antagonists.
Kym PR, Kort ME, Hutchins CW. Kym PR, et al. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. doi: 10.1016/j.bcp.2009.02.014. Epub 2009 Mar 5. Biochem Pharmacol. 2009. PMID: 19481638
Analgesic potential of TRPV3 antagonists.
Reilly RM, Kym PR. Reilly RM, et al. Among authors: kym pr. Curr Top Med Chem. 2011;11(17):2210-5. doi: 10.2174/156802611796904889. Curr Top Med Chem. 2011. PMID: 21671874 Review.
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.
Reilly RM, McDonald HA, Puttfarcken PS, Joshi SK, Lewis L, Pai M, Franklin PH, Segreti JA, Neelands TR, Han P, Chen J, Mantyh PW, Ghilardi JR, Turner TM, Voight EA, Daanen JF, Schmidt RG, Gomtsyan A, Kort ME, Faltynek CR, Kym PR. Reilly RM, et al. Among authors: kym pr. J Pharmacol Exp Ther. 2012 Aug;342(2):416-28. doi: 10.1124/jpet.111.190314. Epub 2012 May 8. J Pharmacol Exp Ther. 2012. PMID: 22570364
83 results