Kleim JP - Search Results

1

Antiviral activity and safety of aplaviroc with lamivudine/zidovudine in HIV-infected, therapy-naive patients: the ASCENT (CCR102881) study.

Currier J, Lazzarin A, Sloan L, Clumeck N, Slims J, McCarty D, Steel H, Kleim JP, Bonny T, Millard J; ASCENT study team. Currier J, et al. Among authors: kleim jp. Antivir Ther. 2008;13(2):297-306. Antivir Ther. 2008. PMID: 18505181 Clinical Trial.

2

GW420867X administered to HIV-1-infected patients alone and in combination with lamivudine and zidovudine.

Arasteh K, Wood R, Müller M, Prince W, Cass L, Moore KH, Dallow N, Jones A, Klein A, Burt V, Kleim JP. Arasteh K, et al. Among authors: kleim jp. HIV Clin Trials. 2001 Jul-Aug;2(4):307-16. doi: 10.1310/03CY-NCM5-8DQG-L2KY. HIV Clin Trials. 2001. PMID: 11590533 Clinical Trial.

3

Antiviral activity of the human immunodeficiency virus type 1-specific nonnucleoside reverse transcriptase inhibitor HBY 097 alone and in combination with zidovudine in a phase II study. HBY 097/2001 Study Group.

Kleim JP, Winters M, Dunkler A, Suarez JR, Riess G, Winkler I, Balzarini J, Oette D, Merigan TC. Kleim JP, et al. J Infect Dis. 1999 Mar;179(3):709-13. doi: 10.1086/314633. J Infect Dis. 1999. PMID: 9952383 Clinical Trial.

4

Absence of zidovudine resistance in antiretroviral-naive patients following zidovudine/lamivudine/protease inhibitor combination therapy: virological evaluation of the AVANTI 2 and AVANTI 3 studies.

Maguire M, Gartland M, Moore S, Hill A, Tisdale M, Harrigan R, Kleim JP. Maguire M, et al. Among authors: kleim jp. AIDS. 2000 Jun 16;14(9):1195-201. doi: 10.1097/00002030-200006160-00017. AIDS. 2000. PMID: 10894284 Clinical Trial.

5

Zidovudine-resistant human immunodeficiency virus type 1 strains subcultured in the presence of both lamivudine and quinoxaline HBY 097 retain marked sensitivity to HBY 097 but not to lamivudine.

Balzarini J, Pelemans H, Riess G, Roesner M, Winkler I, De Clercq E, Kleim JP. Balzarini J, et al. Among authors: kleim jp. J Infect Dis. 1997 Nov;176(5):1392-7. doi: 10.1086/517329. J Infect Dis. 1997. PMID: 9359746

6

In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure of the nonnucleoside reverse transcriptase inhibitor HBY 097.

Kleim JP, Winkler I, Rösner M, Kirsch R, Rübsamen-Waigmann H, Paessens A, Riess G. Kleim JP, et al. Virology. 1997 Apr 28;231(1):112-8. doi: 10.1006/viro.1997.8513. Virology. 1997. PMID: 9143309 Free article.

7

Retention of marked sensitivity to (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-di hydroquin oxaline-2(1H)-thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2',3'-dideoxy-3'-thiacytidine (lamivudine).

Balzarini J, Pelemans H, Riess G, Roesner M, Winkler I, De Clercq E, Kleim JP. Balzarini J, et al. Among authors: kleim jp. Biochem Pharmacol. 1998 Mar 1;55(5):617-25. doi: 10.1016/s0006-2952(97)00506-6. Biochem Pharmacol. 1998. PMID: 9515572

8

Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720.

Balzarini J, Karlsson A, Meichsner C, Paessens A, Riess G, De Clercq E, Kleim JP. Balzarini J, et al. Among authors: kleim jp. J Virol. 1994 Dec;68(12):7986-92. doi: 10.1128/JVI.68.12.7986-7992.1994. J Virol. 1994. PMID: 7525984 Free PMC article.

9

Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication.

Kleim JP, Bender R, Billhardt UM, Meichsner C, Riess G, Rösner M, Winkler I, Paessens A. Kleim JP, et al. Antimicrob Agents Chemother. 1993 Aug;37(8):1659-64. doi: 10.1128/AAC.37.8.1659. Antimicrob Agents Chemother. 1993. PMID: 7692812 Free PMC article.

10

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

Kleim JP, Rösner M, Winkler I, Paessens A, Kirsch R, Hsiou Y, Arnold E, Riess G. Kleim JP, et al. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):34-8. doi: 10.1073/pnas.93.1.34. Proc Natl Acad Sci U S A. 1996. PMID: 8552634 Free PMC article.

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