Bieschke J - Search Results

1

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.

Ehrnhoefer DE, Bieschke J, Boeddrich A, Herbst M, Masino L, Lurz R, Engemann S, Pastore A, Wanker EE. Ehrnhoefer DE, et al. Among authors: bieschke j. Nat Struct Mol Biol. 2008 Jun;15(6):558-66. doi: 10.1038/nsmb.1437. Epub 2008 May 30. Nat Struct Mol Biol. 2008. PMID: 18511942

2

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

Bieschke J, Russ J, Friedrich RP, Ehrnhoefer DE, Wobst H, Neugebauer K, Wanker EE. Bieschke J, et al. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7710-5. doi: 10.1073/pnas.0910723107. Epub 2010 Apr 12. Proc Natl Acad Sci U S A. 2010. PMID: 20385841 Free PMC article.

3

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.

Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, Frank RF, Reif B, Günther S, Walsh DM, Wanker EE. Bieschke J, et al. Nat Chem Biol. 2011 Nov 20;8(1):93-101. doi: 10.1038/nchembio.719. Nat Chem Biol. 2011. PMID: 22101602

4

Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers.

Lopez del Amo JM, Fink U, Dasari M, Grelle G, Wanker EE, Bieschke J, Reif B. Lopez del Amo JM, et al. Among authors: bieschke j. J Mol Biol. 2012 Aug 24;421(4-5):517-24. doi: 10.1016/j.jmb.2012.01.013. Epub 2012 Jan 28. J Mol Biol. 2012. PMID: 22300765

5

Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics.

Verzini S, Shah M, Theillet FX, Belsom A, Bieschke J, Wanker EE, Rappsilber J, Binolfi A, Selenko P. Verzini S, et al. Among authors: bieschke j. J Mol Biol. 2020 Dec 4;432(24):166689. doi: 10.1016/j.jmb.2020.10.023. Epub 2020 Oct 22. J Mol Biol. 2020. PMID: 33211011 Free PMC article.

6

Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils.

Grelle G, Otto A, Lorenz M, Frank RF, Wanker EE, Bieschke J. Grelle G, et al. Among authors: bieschke j. Biochemistry. 2011 Dec 13;50(49):10624-36. doi: 10.1021/bi2012383. Epub 2011 Nov 16. Biochemistry. 2011. PMID: 22054421

7

The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.

Wobst HJ, Sharma A, Diamond MI, Wanker EE, Bieschke J. Wobst HJ, et al. Among authors: bieschke j. FEBS Lett. 2015 Jan 2;589(1):77-83. doi: 10.1016/j.febslet.2014.11.026. Epub 2014 Nov 29. FEBS Lett. 2015. PMID: 25436420 Free PMC article.

8

Amyloid-β(1-42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity.

Jin S, Kedia N, Illes-Toth E, Haralampiev I, Prisner S, Herrmann A, Wanker EE, Bieschke J. Jin S, et al. Among authors: bieschke j. J Biol Chem. 2016 Sep 9;291(37):19590-606. doi: 10.1074/jbc.M115.691840. Epub 2016 Jul 25. J Biol Chem. 2016. PMID: 27458018 Free PMC article.

9

670 nm laser light and EGCG complementarily reduce amyloid-β aggregates in human neuroblastoma cells: basis for treatment of Alzheimer's disease?

Sommer AP, Bieschke J, Friedrich RP, Zhu D, Wanker EE, Fecht HJ, Mereles D, Hunstein W. Sommer AP, et al. Among authors: bieschke j. Photomed Laser Surg. 2012 Jan;30(1):54-60. doi: 10.1089/pho.2011.3073. Epub 2011 Oct 26. Photomed Laser Surg. 2012. PMID: 22029866

10

Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate.

Andrich K, Hegenbart U, Kimmich C, Kedia N, Bergen HR 3rd, Schönland S, Wanker E, Bieschke J. Andrich K, et al. Among authors: bieschke j. J Biol Chem. 2017 Feb 10;292(6):2328-2344. doi: 10.1074/jbc.M116.750323. Epub 2016 Dec 28. J Biol Chem. 2017. PMID: 28031465 Free PMC article.

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