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Superficial zone chondrocytes in normal and osteoarthritic human articular cartilages synthesize novel truncated forms of inter-alpha-trypsin inhibitor heavy chains which are attached to a chondroitin sulfate proteoglycan other than bikunin.
Yoshihara Y, Plaas A, Osborn B, Margulis A, Nelson F, Stewart M, Rugg MS, Milner CM, Day AJ, Nemoto K, Sandy JD. Yoshihara Y, et al. Among authors: plaas a. Osteoarthritis Cartilage. 2008 Nov;16(11):1343-55. doi: 10.1016/j.joca.2008.04.004. Epub 2008 Jun 3. Osteoarthritis Cartilage. 2008. PMID: 18524635 Free article.
Biosynthesis of cartilage proteoglycan and link protein by articular chondrocytes from immature and mature rabbits.
Plaas AH, Sandy JD, Kimura JH. Plaas AH, et al. J Biol Chem. 1988 Jun 5;263(16):7560-6. J Biol Chem. 1988. PMID: 3372500 Free article.
While cell layer retention of newly synthesized proteoglycan was markedly lower in mature relative to immature cell cultures, link protein retention was high in both immature and mature cultures; this finding provides an explanation for our previous observation (Plaas, …
While cell layer retention of newly synthesized proteoglycan was markedly lower in mature relative to immature cell cultures, link protein r …
The affinity of newly synthesized proteoglycan for hyaluronic acid can be enhanced by exposure to mild alkali.
Plaas AH, Sandy JD. Plaas AH, et al. Biochem J. 1986 Feb 15;234(1):221-3. doi: 10.1042/bj2340221. Biochem J. 1986. PMID: 3707543 Free PMC article.
In mixtures prepared at pH 6.8 the newly synthesized proteoglycan had the lower affinity; however, in mixtures incubated at pH 8.5 for 24 h before addition of hyaluronic acid, the newly synthesized proteoglycan exhibited a markedly higher affinity than the bovine monomer. …
In mixtures prepared at pH 6.8 the newly synthesized proteoglycan had the lower affinity; however, in mixtures incubated at pH 8.5 for 24 h …
105 results