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819 results

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Page 1
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
Shipe WD, Barrow JC, Yang ZQ, Lindsley CW, Yang FV, Schlegel KA, Shu Y, Rittle KE, Bock MG, Hartman GD, Tang C, Ballard JE, Kuo Y, Adarayan ED, Prueksaritanont T, Zrada MM, Uebele VN, Nuss CE, Connolly TM, Doran SM, Fox SV, Kraus RL, Marino MJ, Graufelds VK, Vargas HM, Bunting PB, Hasbun-Manning M, Evans RM, Koblan KS, Renger JJ. Shipe WD, et al. Among authors: evans rm. J Med Chem. 2008 Jul 10;51(13):3692-5. doi: 10.1021/jm800419w. Epub 2008 Jun 10. J Med Chem. 2008. PMID: 18540666
Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.
Li Z, Chen W, Hale JJ, Lynch CL, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Parent SA, Bergstrom J, Card D, Forrest M, Quackenbush EJ, Wickham LA, Vargas H, Evans RM, Rosen H, Mandala S. Li Z, et al. Among authors: evans rm. J Med Chem. 2005 Oct 6;48(20):6169-73. doi: 10.1021/jm0503244. J Med Chem. 2005. PMID: 16190743
Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming.
Yang Y, Zhang X, Cai D, Zheng X, Zhao X, Zou JX, Zhang J, Borowsky AD, Dall'Era MA, Corey E, Mitsiades N, Kung HJ, Chen X, Li JJ, Downes M, Evans RM, Chen HW. Yang Y, et al. Among authors: evans rm. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2411321121. doi: 10.1073/pnas.2411321121. Epub 2024 Oct 9. Proc Natl Acad Sci U S A. 2024. PMID: 39383000 Free PMC article.
The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice.
Pessentheiner AR, Spann NJ, Autran CA, Oh TG, Grunddal KV, Coker JK, Painter CD, Ramms B, Chiang AW, Wang CY, Hsiao J, Wang Y, Quach A, Booshehri LM, Hammond A, Tognaccini C, Latasiewicz J, Willemsen L, Zengler K, de Winther MP, Hoffman HM, Philpott M, Cribbs AP, Oppermann U, Lewis NE, Witztum JL, Yu R, Atkins AR, Downes M, Evans RM, Glass CK, Bode L, Gordts PL. Pessentheiner AR, et al. Among authors: evans rm. JCI Insight. 2024 Nov 8;9(21):e181329. doi: 10.1172/jci.insight.181329. JCI Insight. 2024. PMID: 39325548 Free PMC article.
Nuclear receptor corepressor 1 levels differentially impact the intracellular dynamics of mutant thyroid hormone receptors associated with resistance to thyroid hormone syndrome.
Simsek YK, Tofil HP, Rosenthal MI, Evans RM, Danielski CL, Beasley KE, Alsayed H, Shapira ME, Strauss RI, Wang M, Roggero VR, Allison LA. Simsek YK, et al. Among authors: evans rm. Mol Cell Endocrinol. 2024 Dec 1;594:112373. doi: 10.1016/j.mce.2024.112373. Epub 2024 Sep 17. Mol Cell Endocrinol. 2024. PMID: 39299378 Free article.
CAnceR IN PreGnancy (CARING) - a retrospective study of cancer diagnosed during pregnancy in the United Kingdom.
Baxter MA, Denholm M, Kingdon SJ, Kathirgamakarthigeyan S, Parikh S, Shakir R, Johnson R, Martin H, Walton M, Yao W, Swan A, Samuelson C, Ren X, Cooper A, Gray HL, Clifton S, Ball J, Gullick G, Anderson M, Dodd L, Hayhurst H, Salama M, Shotton R, Britton F, Christodoulou T, Abdul-Hamid A, Eichholz A, Evans RM, Wallroth P, Gibson F, Poole K, Rowe M, Harris J; National Oncology Trainees Collaborative for Healthcare Research (NOTCH). Baxter MA, et al. Among authors: evans rm. Br J Cancer. 2024 May;130(8):1261-1268. doi: 10.1038/s41416-024-02605-x. Epub 2024 Feb 21. Br J Cancer. 2024. PMID: 38383704 Free PMC article.
Targeting nuclear receptor corepressors for reversible male contraception.
Hong SH, Castro G, Wang D, Nofsinger R, Kane M, Folias A, Atkins AR, Yu RT, Napoli JL, Sassone-Corsi P, de Rooij DG, Liddle C, Downes M, Evans RM. Hong SH, et al. Among authors: evans rm. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2320129121. doi: 10.1073/pnas.2320129121. Epub 2024 Feb 20. Proc Natl Acad Sci U S A. 2024. PMID: 38377195 Free PMC article.
Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.
Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. Xia W, et al. Among authors: evans rm. Nat Metab. 2024 Feb;6(2):273-289. doi: 10.1038/s42255-024-00978-0. Epub 2024 Jan 29. Nat Metab. 2024. PMID: 38286821 Free PMC article.
819 results