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Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation.
Langeveld M, van den Berg SA, Bijl N, Bijland S, van Roomen CP, Houben-Weerts JH, Ottenhoff R, Houten SM, van Dijk KW, Romijn JA, Groen AK, Aerts JM, Voshol PJ. Langeveld M, et al. Among authors: bijl n. Metabolism. 2012 Jan;61(1):99-107. doi: 10.1016/j.metabol.2011.05.013. Epub 2011 Aug 3. Metabolism. 2012. PMID: 21816446
Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.
van Eijk M, Aten J, Bijl N, Ottenhoff R, van Roomen CP, Dubbelhuis PF, Seeman I, Ghauharali-van der Vlugt K, Overkleeft HS, Arbeeny C, Groen AK, Aerts JM. van Eijk M, et al. Among authors: bijl n. PLoS One. 2009;4(3):e4723. doi: 10.1371/journal.pone.0004723. Epub 2009 Mar 23. PLoS One. 2009. PMID: 19305508 Free PMC article.
Glycosphingolipids and insulin resistance.
Aerts JM, Boot RG, van Eijk M, Groener J, Bijl N, Lombardo E, Bietrix FM, Dekker N, Groen AK, Ottenhoff R, van Roomen C, Aten J, Serlie M, Langeveld M, Wennekes T, Overkleeft HS. Aerts JM, et al. Among authors: bijl n. Adv Exp Med Biol. 2011;721:99-119. doi: 10.1007/978-1-4614-0650-1_7. Adv Exp Med Biol. 2011. PMID: 21910085 Review.
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, van Eijk M, Ottenhoff R, Bijl N, Ghauharali K, Song H, O'Shea TJ, Liu H, Yew N, Copeland D, van den Berg RJ, van der Marel GA, Overkleeft HS, Aerts JM. Wennekes T, et al. Among authors: bijl n. J Med Chem. 2010 Jan 28;53(2):689-98. doi: 10.1021/jm901281m. J Med Chem. 2010. PMID: 20000679
C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia.
Bakker AB, van den Oudenrijn S, Bakker AQ, Feller N, van Meijer M, Bia JA, Jongeneelen MA, Visser TJ, Bijl N, Geuijen CA, Marissen WE, Radosevic K, Throsby M, Schuurhuis GJ, Ossenkoppele GJ, de Kruif J, Goudsmit J, Kruisbeek AM. Bakker AB, et al. Among authors: bijl n. Cancer Res. 2004 Nov 15;64(22):8443-50. doi: 10.1158/0008-5472.CAN-04-1659. Cancer Res. 2004. PMID: 15548716
39 results