Beghyn T - Search Results

1

Natural compounds: leads or ideas? Bioinspired molecules for drug discovery.

Beghyn T, Deprez-Poulain R, Willand N, Folleas B, Deprez B. Beghyn T, et al. Chem Biol Drug Des. 2008 Jul;72(1):3-15. doi: 10.1111/j.1747-0285.2008.00673.x. Epub 2008 Jun 11. Chem Biol Drug Des. 2008. PMID: 18554253

2

A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening.

Flipo M, Beghyn T, Charton J, Leroux VA, Deprez BP, Deprez-Poulain RF. Flipo M, et al. Among authors: beghyn t. Bioorg Med Chem. 2007 Jan 1;15(1):63-76. doi: 10.1016/j.bmc.2006.10.010. Epub 2006 Oct 12. Bioorg Med Chem. 2007. PMID: 17070058

3

PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil.

Beghyn T, Hounsou C, Deprez BP. Beghyn T, et al. Bioorg Med Chem Lett. 2007 Feb 1;17(3):789-92. doi: 10.1016/j.bmcl.2006.10.069. Epub 2006 Oct 27. Bioorg Med Chem Lett. 2007. PMID: 17107795

4

Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.

Flipo M, Beghyn T, Leroux V, Florent I, Deprez BP, Deprez-Poulain RF. Flipo M, et al. Among authors: beghyn t. J Med Chem. 2007 Mar 22;50(6):1322-34. doi: 10.1021/jm061169b. Epub 2007 Feb 28. J Med Chem. 2007. PMID: 17326615

5

Drug to genome to drug: discovery of new antiplasmodial compounds.

Beghyn TB, Charton J, Leroux F, Laconde G, Bourin A, Cos P, Maes L, Deprez B. Beghyn TB, et al. J Med Chem. 2011 May 12;54(9):3222-40. doi: 10.1021/jm1014617. Epub 2011 Apr 19. J Med Chem. 2011. PMID: 21504142

6

Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds.

Beghyn TB, Charton J, Leroux F, Henninot A, Reboule I, Cos P, Maes L, Deprez B. Beghyn TB, et al. J Med Chem. 2012 Feb 9;55(3):1274-86. doi: 10.1021/jm201422e. Epub 2012 Jan 24. J Med Chem. 2012. PMID: 22204607

7

Rescue of nonsense mutations by amlexanox in human cells.

Gonzalez-Hilarion S, Beghyn T, Jia J, Debreuck N, Berte G, Mamchaoui K, Mouly V, Gruenert DC, Déprez B, Lejeune F. Gonzalez-Hilarion S, et al. Among authors: beghyn t. Orphanet J Rare Dis. 2012 Aug 31;7:58. doi: 10.1186/1750-1172-7-58. Orphanet J Rare Dis. 2012. PMID: 22938201 Free PMC article.

8

In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy.

Karrout Y, Dubuquoy L, Piveteau C, Siepmann F, Moussa E, Wils D, Beghyn T, Neut C, Flament MP, Guerin-Deremaux L, Dubreuil L, Deprez B, Desreumaux P, Siepmann J. Karrout Y, et al. Among authors: beghyn t. J Control Release. 2015 Jan 10;197:121-30. doi: 10.1016/j.jconrel.2014.11.006. Epub 2014 Nov 10. J Control Release. 2015. PMID: 25445696

9

Characterization of monoclonal antibodies by a fast and easy liquid chromatography-mass spectrometry time-of-flight analysis on culture supernatant.

Henninot A, Terrier A, Charton J, Urbain R, Fontayne A, Deprez B, Beghyn T. Henninot A, et al. Among authors: beghyn t. Anal Biochem. 2015 Dec 15;491:52-4. doi: 10.1016/j.ab.2015.08.006. Epub 2015 Aug 22. Anal Biochem. 2015. PMID: 26302360

10

Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening.

Leroux F, Bosc D, Beghyn T, Hermant P, Warenghem S, Landry V, Pottiez V, Guillaume V, Charton J, Herledan A, Urata S, Liang W, Sheng L, Tang WJ, Deprez B, Deprez-Poulain R. Leroux F, et al. Among authors: beghyn t. Eur J Med Chem. 2019 Oct 1;179:557-566. doi: 10.1016/j.ejmech.2019.06.057. Epub 2019 Jun 24. Eur J Med Chem. 2019. PMID: 31276900 Free PMC article.

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