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First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone.
Nagelschmitz J, Voith B, Wensing G, Roemer A, Fugmann B, Haynes RK, Kotecka BM, Rieckmann KH, Edstein MD. Nagelschmitz J, et al. Among authors: haynes rk. Antimicrob Agents Chemother. 2008 Sep;52(9):3085-91. doi: 10.1128/AAC.01585-07. Epub 2008 Jun 16. Antimicrob Agents Chemother. 2008. PMID: 18559649 Free PMC article. Clinical Trial.
Artemisone--a highly active antimalarial drug of the artemisinin class.
Haynes RK, Fugmann B, Stetter J, Rieckmann K, Heilmann HD, Chan HW, Cheung MK, Lam WL, Wong HN, Croft SL, Vivas L, Rattray L, Stewart L, Peters W, Robinson BL, Edstein MD, Kotecka B, Kyle DE, Beckermann B, Gerisch M, Radtke M, Schmuck G, Steinke W, Wollborn U, Schmeer K, Römer A. Haynes RK, et al. Angew Chem Int Ed Engl. 2006 Mar 20;45(13):2082-8. doi: 10.1002/anie.200503071. Angew Chem Int Ed Engl. 2006. PMID: 16444785 No abstract available.
Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.
Coertzen D, Reader J, van der Watt M, Nondaba SH, Gibhard L, Wiesner L, Smith P, D'Alessandro S, Taramelli D, Wong HN, du Preez JL, Wu RWK, Birkholtz LM, Haynes RK. Coertzen D, et al. Among authors: haynes rk. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e02214-17. doi: 10.1128/AAC.02214-17. Print 2018 Aug. Antimicrob Agents Chemother. 2018. PMID: 29866868 Free PMC article.
Neurotoxic mode of action of artemisinin.
Schmuck G, Roehrdanz E, Haynes RK, Kahl R. Schmuck G, et al. Among authors: haynes rk. Antimicrob Agents Chemother. 2002 Mar;46(3):821-7. doi: 10.1128/AAC.46.3.821-827.2002. Antimicrob Agents Chemother. 2002. PMID: 11850267 Free PMC article.
Artemisone uptake in Plasmodium falciparum-infected erythrocytes.
Pooley S, Fatih FA, Krishna S, Gerisch M, Haynes RK, Wong HN, Staines HM. Pooley S, et al. Among authors: haynes rk. Antimicrob Agents Chemother. 2011 Feb;55(2):550-6. doi: 10.1128/AAC.01216-10. Epub 2010 Dec 6. Antimicrob Agents Chemother. 2011. PMID: 21135191 Free PMC article.
102 results