LaVallee TM - Search Results

1

Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.

LaVallee TM, Burke PA, Swartz GM, Hamel E, Agoston GE, Shah J, Suwandi L, Hanson AD, Fogler WE, Sidor CF, Treston AM. LaVallee TM, et al. Mol Cancer Ther. 2008 Jun;7(6):1472-82. doi: 10.1158/1535-7163.MCT-08-0107. Mol Cancer Ther. 2008. PMID: 18566218

2

Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol.

Agoston GE, Shah JH, Lavallee TM, Zhan X, Pribluda VS, Treston AM. Agoston GE, et al. Among authors: lavallee tm. Bioorg Med Chem. 2007 Dec 15;15(24):7524-37. doi: 10.1016/j.bmc.2007.09.011. Epub 2007 Sep 14. Bioorg Med Chem. 2007. PMID: 17910916

3

Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol.

Shah JH, Agoston GE, Suwandi L, Hunsucker K, Pribluda V, Zhan XH, Swartz GM, LaVallee TM, Treston AM. Shah JH, et al. Among authors: lavallee tm. Bioorg Med Chem. 2009 Oct 15;17(20):7344-52. doi: 10.1016/j.bmc.2009.08.038. Epub 2009 Aug 21. Bioorg Med Chem. 2009. PMID: 19762246

4

Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol.

Agoston GE, Shah JH, Suwandi L, Hanson AD, Zhan X, LaVallee TM, Pribluda V, Treston AM. Agoston GE, et al. Among authors: lavallee tm. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6241-4. doi: 10.1016/j.bmcl.2009.08.020. Epub 2009 Aug 8. Bioorg Med Chem Lett. 2009. PMID: 19782564

5

Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs.

Suwandi LS, Agoston GE, Shah JH, Hanson AD, Zhan XH, Lavallee TM, Treston AM. Suwandi LS, et al. Among authors: lavallee tm. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6459-62. doi: 10.1016/j.bmcl.2009.09.009. Epub 2009 Sep 9. Bioorg Med Chem Lett. 2009. PMID: 19782568

6

2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway.

LaVallee TM, Zhan XH, Johnson MS, Herbstritt CJ, Swartz G, Williams MS, Hembrough WA, Green SJ, Pribluda VS. LaVallee TM, et al. Cancer Res. 2003 Jan 15;63(2):468-75. Cancer Res. 2003. PMID: 12543804

7

2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate.

Pribluda VS, Gubish ER Jr, Lavallee TM, Treston A, Swartz GM, Green SJ. Pribluda VS, et al. Among authors: lavallee tm. Cancer Metastasis Rev. 2000;19(1-2):173-9. doi: 10.1023/a:1026543018478. Cancer Metastasis Rev. 2000. PMID: 11191057 Review.

8

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P. Mabjeesh NJ, et al. Among authors: lavallee tm. Cancer Cell. 2003 Apr;3(4):363-75. doi: 10.1016/s1535-6108(03)00077-1. Cancer Cell. 2003. PMID: 12726862 Free article.

9

The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression.

Escuin D, Burke PA, McMahon-Tobin G, Hembrough T, Wang Y, Alcaraz AA, Leandro-García LJ, Rodríguez-Antona C, Snyder JP, Lavallee TM, Giannakakou P. Escuin D, et al. Among authors: lavallee tm. Cell Cycle. 2009 Dec;8(23):3914-24. doi: 10.4161/cc.8.23.10105. Epub 2009 Dec 16. Cell Cycle. 2009. PMID: 19901556

10

2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.

LaVallee TM, Zhan XH, Herbstritt CJ, Kough EC, Green SJ, Pribluda VS. LaVallee TM, et al. Cancer Res. 2002 Jul 1;62(13):3691-7. Cancer Res. 2002. PMID: 12097276

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